Scientist, LNP Formulations
About The Position
FL87, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. It was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture. The role We are seeking an experienced Lipid Nanoparticle (LNP) Formulation Scientist to drive the design, execution, and analysis of Design of Experiments (DOE) aimed at innovating next-generation LNP formulations. This role will play a critical part in developing, optimizing, and characterizing LNP systems for nucleic acid delivery in a fast-paced, collaborative research environment.
Requirements
- PhD or MS in Chemistry, Pharmaceutical Sciences, Chemical Engineering, Materials Science, or a related field
- Strong hands-on experience with LNP formulations, including formulation development and optimization
- Demonstrated expertise in DOE methodologies and statistical experimental design
- Extensive experience with LNP screening and analytical techniques (e.g., DLS, encapsulation assays, stability studies, physicochemical characterization)
- Deep understanding of lipid-based delivery systems and formulation science principles
- Proven ability to work effectively in a team-oriented, fast-paced environment
- Strong problem-solving skills and ability to manage multiple priorities simultaneously
- Strong communication skills for presenting data and influencing technical decisions
Responsibilities
- Design, execute, and analyze DOE-based formulation experiments to develop and optimize novel LNP formulations
- Lead formulation innovation efforts, including lipid selection, composition optimization, and process parameter evaluation
- Perform LNP screening and characterization, including size, PDI, encapsulation efficiency, stability, and performance metrics
- Apply strong analytical and statistical approaches to interpret complex datasets and guide formulation decisions
- Collaborate closely with cross-functional teams (biology, analytics, process development, and project management) to advance programs
- Maintain thorough experimental documentation and clearly communicate results and recommendations to stakeholders
- Contribute to troubleshooting formulation challenges and continuously improve experimental workflows
- Support scale-up considerations and technology transfer as needed
Benefits
- Opportunity to work at the forefront of LNP formulation innovation
- Collaborative, science-driven culture with high impact research
- Competitive compensation and benefits package
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
Number of Employees
501-1,000 employees
