Scientist l, In Vivo Pharmacology

AbbVie • North Chicago, IL

261d

About The Position

Our In Vivo Pharmacology group in Lake County, IL has an opening for a motivated in vivo pharmacologist who is dedicated to the discovery and development of innovative treatments. The position involves working with both small molecule and biological therapeutics, with a focus on diseases of aging such as mitochondrial, metabolic, peripheral organ diseases, and fibrotic disorders. Primary responsibilities include independently executing, reporting, and troubleshooting in vivo pharmacology studies based on previous hands-on experience and foundational theoretical knowledge. The scientist will work on preclinical in vivo models in mice and rats for age-related diseases (e.g., fibrosis, immune, kidney, metabolic, or cardiovascular) as well as mechanism of action and Pharmacokinetics/ Pharmacodynamic (PK/PD) studies. The position requires interaction with in vivo / in vitro biology, translational/ biomarkers, PK and medicinal chemistry teams to advance therapeutic agents through the R D pipeline.

Requirements

• Bachelor's Degree or equivalent education with typically 5 years of experience, or Master's Degree or equivalent education with typically two years of experience
• Proven expertise with design and execution of studies utilizing in vivo / ex vivo techniques in rodents is required
• Experience with drug formulation and administration to rodents via SC, PO, IP, and IV routes
• Experience utilizing in vivo / ex vivo techniques in rodents, including physiological measurements, tissue collection, and analysis by biochemical or histological methods
• Strong problem-solving skills
• Familiarity with data graphing, data analysis, presentations, and statistical software (e.g. Microsoft Office Suite, Prism)
• Good communication skills and willingness to work with a cross-functional team of researchers

Nice To Haves

• Experience with ELISA / MSD / Western Blots / biochemical assays, flow cytometry and/or immunohistochemistry is desired
• Experience in ex vivo processing of tissues (homogenization, RNA extraction) and analyses (ELISA, MSD, flow cytometry, WB, PCR, biochemical assays, multiplex platform) is desired

Responsibilities

• Acts as Study Leader/Coordinator for assigned studies and demonstrates proficiency in general in vivo procedures in mice and rats including dosing
• Maintains competency in all aspects of rodent handling and treatment dosing of small molecules and biologics in mice and rats
• Develops and optimizes new methods/techniques to generate reliable and reproducible data in a timely manner
• Using an electronic notebook to maintain proprietary study records
• Working closely with his/her supervisor to schedule and prioritize workload to manage several tasks simultaneously
• Exhibiting excellent communication skills and the ability to present data clearly and thoroughly in both one-on-one interactions and group meetings

What This Job Offers

• Job Type: Full-time
• Industry: Chemical Manufacturing
• Education Level: Bachelor's degree