Scientist, In Vivo Pharmacology, Inflammation Research

Amgen • Thousand Oaks, CA

5d

About The Position

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Scientist, In Vivo Pharmacology, Inflammation Research What you will do Let’s do this. Let’s change the world. In this vital role you will work in a highly dynamic in vivo pharmacology team executing in vivo preclinical disease models and in vitro assays in the vivarium and lab supporting pipeline programs managing interactions and presentation of results with project teams and collaborators.

Requirements

• Doctorate degree OR Master’s degree and 2 years of Immunology or related experience OR Bachelor’s degree and 4 years of Immunology or related experience

Nice To Haves

• PhD degree and post-doctoral training (or drug discovery experience) in the fields of Immunology, inflammation autoimmune disease, or related disciplines.
• Strong understanding of Immunology and Inflammation biology and principles.
• Willingness and curiosity to learn and explore new areas of research.
• Experience executing in vivo preclinical respiratory disease models, including asthma (OVA, HDM), COPD (Elastase, smoke extract), Bleomycin fibrosis (i.t., i.d., s.c.), respiratory virus infection (PR8) models preferred.
• Experience with preclinical inflammatory disease models, including colitis, lupus, RA, PBC important.
• Significant Experience with lung function measurements (FlexiVent, Plethysmography), imaging (mCT), and inhaled drug delivery preferred.
• Hands-on experience with in vivo techniques including dosing route of administration (i.v., i.p., p.o., i.n., i.t., r.o., i.d., s.c.), bleeds (r.o., cheek, tail), necropsy (organ collection (intestine/colon, lung, lymphnodes, spleen, liver, kidney, skin), cardiac bleed, lung BAL collection).
• Hands-on experience in cellular, biochemical, histological, and molecular biology assay techniques (i.e. ELISA, MSD, multi-color flow cytometry, quantitative RT-PCR) preferred.
• Computer literacy, especially proficiency with GraphPad Prism, Excel, PowerPoint and Word.
• Attention to detail, excellent organizational and communication kills, accurate & timely record keeping and data analysis are essential.
• Demonstrated track record of independent critical thinking and scientific achievement.
• Demonstrated experience in and understanding of pharmacology with application using in vivo models of inflammation/Immunology.
• Experience working on project teams leading in vivo contributions.
• Ability to work in a flexible team-oriented environment.
• Weekend and evening work may be required.

Responsibilities

• Perform hands-on in vivo work primarily mice, possibly rats and run concurrent studies
• Design experiments and execute studies, working alongside senior scientists and associate scientists
• Generate high-quality experimental data and ensure studies are organized and prepared
• Supervise/coordinate associate scientists tasks/time as needed for study execution.
• Analyze and communicate results to project teams and the broader department
• Understand the biology of supported projects and contribute to project progression
• Participate in occasional weekend/evening dosing rotations as required.

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees