Scientist II/Sr. Scientist I, Specificity Screening of Epigenome Editors

Scribe Therapeutics is seeking a Scientist to join their Genotoxicity team and contribute to the development of safe and effective CRISPR-based therapeutics. The role involves utilizing expertise in next-generation sequencing, epigenomics, and molecular biology to develop assays for detecting on- and off-target epigenome editing. The ideal candidate will have experience in epigenomic assay development and a passion for collaborating with molecular engineers and computational biologists. This position offers opportunities for professional growth, including leadership roles and the ability to publish impactful work. The Scientist will work closely with platform engineering and therapeutic development teams to shape the therapeutic strategy and set new safety standards in the field of therapeutic gene editing.

• Work closely with Scribe’s teams to develop assays to assess the potential off-target effects of CRISPR-based epigenomic editors across a range of enzymes, targets, and delivery systems
• Formulate scientific strategies for specificity assessments of Scribe’s epigenomic editing platform and work with external teams to execute these activities
• Collaborate across pre-clinical therapeutic groups both within the company and externally to drive rapid advancement of new targets and molecules
• Ensure high quality data generation through proper assay validation and qualification
• Assume project responsibilities and effectively present updates, and communicate research plans and timelines to the senior leadership team internally and partners externally
• Mentor junior team members
• Seamlessly interface and coordinate with other teams at Scribe to accomplish common goals
• Foster a driven, fast-paced, dynamic, and fun environment in which to do rigorous science

• PhD in molecular biology, cell biology, genetics, bioengineering or related field. A postdoc and/or 1+ years industry experience is a plus
• Experience with a range of assay development in next-generation sequencing, epigenomics, and molecular biology
• Passion for working collaboratively with molecular engineers and computational biologists
• Hands-on experience with epigenomic assay development
• Desire to build novel strategies for screening the specificity of Scribe's epigenome editing platform
• Ability to work closely with teams to develop assays to assess the potential off-target effects of CRISPR-based epigenomic editors
• Formulate scientific strategies for specificity assessments of Scribe's epigenomic editing platform
• Collaborate across pre-clinical therapeutic groups to drive rapid advancement of new targets and molecules
• Ensure high quality data generation through proper assay validation and qualification
• Ability to assume project responsibilities and effectively present updates, research plans, and timelines
• Mentorship skills to guide junior team members
• Ability to seamlessly interface and coordinate with other teams at Scribe
• Foster a driven, fast-paced, dynamic, and fun environment for rigorous science.

• Professional growth opportunities
• Leadership roles of increasing responsibilities
• Ability to publish highly impactful work in peer-reviewed journals
• Collaboration with platform engineering teams and therapeutic development teams
• Opportunity to develop therapeutic strategy from beginning to end
• Setting new standards for safety in therapeutic gene editing
• Mentorship opportunities for junior team members
• Seamless interface and coordination with other teams
• Driven, fast-paced, dynamic, and fun work environment
• Salary commensurate with experience
• Intellectually stimulating and collegial environment
• Commitment to diversity and equal opportunity employment