Scientist II/Sr. Scientist I, Antibody Engineering
About The Position
At Firefly Bio, our mission is to redefine cancer treatment. We are developing a new class of therapeutics called Degrader Antibody Conjugates (DACs), which combine the precision of antibodies with the power of selective protein degraders. Our goal is to unlock new classes of payloads and deliver transformative medicines to patients. Our team operates with Focus, Integrity, Respect, and Energy. Position Summary Firefly Bio is seeking a highly motivated Scientist II/Senior Scientist I to join our Protein Sciences team. This is a hands-on, predominantly laboratory-based role, essential to the development of phage display capabilities for antibody discovery and engineering. The successful candidate will contribute to advancing our proprietary Degrader Antibody Conjugates (DACS) from early discovery through lead nomination.
Requirements
- M.S. or Ph.D. in molecular biology, biochemistry, protein engineering, or a related discipline.
- 3-5 years of hands-on experience in phage display and other antibody display technologies, preferably within an industry setting.
- Expertise in molecular cloning techniques, including PCR, restriction digestion, ligation, DNA gel purification, and bacterial transformation is a must.
- Experience with library construction using various molecular cloning skills is required.
- Proficiency in sample preparation for sequencing and repertoire analysis using both NGS and Sanger sequencing is required.
- Strong communication, organizational, and problem-solving abilities are preferred.
Responsibilities
- Establish and develop phage display methodologies within the team to engineer novel antibody attributes.
- Explore alternate display platforms and bispecific formats.
- Apply structure- and sequence-based strategies to optimize antibody affinity, specificity, developability, and stability.
- Contribute to molecular cloning, site-directed mutagenesis, high-throughput expression and purification of antibodies (mg to gram scale).
- Present research findings at internal meetings.
- Maintain meticulous laboratory records and support patent filings and scientific publications.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Industry
Professional, Scientific, and Technical Services
Education Level
Ph.D. or professional degree
Number of Employees
11-50 employees
