Scientist II - in vitro ADME/Transporter Sciences

AbbVie • South San Francisco, CA

412d

About The Position

The Scientist II - in vitro ADME/Transporter Sciences position at AbbVie involves conducting in vitro experiments related to drug transporters to support drug discovery and development projects. The role requires collaboration with various scientific disciplines to generate data that informs clinical candidate development and regulatory filings. The successful candidate will engage in scientific innovation projects and contribute to improving data quality and capacity within the team.

Requirements

• A master's or bachelor's degree in a relevant field (pharmacy, pharmacology, pharmaceutical sciences, biological chemistry or equivalent) with relevant industry experience in drug discovery/development (+5 years with MS; +7 years with B.S).
• Excellent skills in handling and understanding of recombinant and primary cell lines (culture, seeding, storage).
• Working experience in in-vitro drug transporters, metabolism, and drug-drug interactions investigations.
• Working experience with LC-MS/MS based bioanalysis of in vitro experimental samples.
• Proficiency in data analysis, maintaining electronic notebook, and generating accurate reports.
• Strong understanding of ADME/DMPK/pharmacokinetics, drug dispositions, and PK/PD principles and practices.
• Knowledge in regulatory guidance and in vitro to in vivo extrapolations (IVIVE) such as PBPK modeling and in-silico ADME predictions.
• Experience conducting in vitro assays with radioisotope and fluorescent labeled compounds is required.
• Working experience with primary hepatocytes, 3D or co-culture models is a plus.
• Strong communication and collaboration skills with flexibility to operate in a team environment.

Nice To Haves

• Experience with primary hepatocytes, 3D or co-culture models.

Responsibilities

• Conducting in vitro transporter experiments using a wide range of in vitro systems such as recombinant transporter and primary cell lines.
• Cell culture, storage, and maintenance of cell repository (recombinant and primary) while collaborating with team members.
• Conducting primary hepatocytes-based in vitro uptake experiments.
• Conducting high-throughput screening for potential inhibition of uptake transporters.
• Analyzing experimental data and maintaining accurate and comprehensible study documentation in real time.
• Participating in scientific development goals to improve data quality, capacity, and introduce new tools and techniques.

Benefits

• Paid time off (vacation, holidays, sick)
• Medical, dental, and vision insurance
• 401(k) plan
• Short-term incentive programs

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Industry: Chemical Manufacturing
• Education Level: Bachelor's degree