Scientist II, Immunology

Anvia Therapertics-posted 2 days ago

$115,000 - $150,000/Yr

Full-time • Mid Level

New York, NY

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Anvia Therapeutics is a dynamic and innovative biotech company dedicated to developing small molecule inhibitors targeted at treating inflammatory and autoimmune diseases. We foster a collaborative environment where scientific excellence and creativity drive our mission to develop impactful medicines. We are seeking a highly motivated immunology Scientist to drive hypothesis-driven in vitro immunology research in a fast-paced and innovative drug discovery environment. The successful candidate will design, develop, and execute complex cellular assay systems, including primary human immune cells, patient-derived samples, and disease-relevant cell lines to support immune pharmacology and mechanism-of-action (MoA) studies across inflammatory disease programs such as IBD, rheumatoid arthritis, and dermal inflammation.

Design and execute hypothesis-driven cellular assays to support immune pharmacology, target validation, and MoA studies.
Develop, optimize, and validate complex in vitro assay systems using primary immune cells, patient-derived samples, and disease-relevant or engineered cell lines.
Perform functional immune assays including cell activation, proliferation, cytokine production, signaling, and cytotoxicity, using both primary and cell-line–based systems.
Contribute to immune pharmacology assessments, including compound potency, pathway modulation, selectivity, and translational relevance.
Apply a strong mechanistic understanding of immune and inflammatory signaling pathways to guide assay design and data interpretation.
Utilize flow cytometry, ELISA/MSD/other cytokine/chemokine profiling techniques, protein- and signaling-based assays, and related techniques to generate high-quality, reproducible data.
Analyze, interpret, and clearly communicate experimental results to project and leadership teams.
Troubleshoot and refine experimental systems to improve robustness, scalability, and biological relevance.
Maintain accurate experimental records using electronic laboratory notebooks.
Collaborate closely with lead discovery, chemistry, translational, and external partners to advance program milestones.
Stay current with emerging immunology technologies and incorporate innovative methodologies where appropriate.

PhD in Immunology, Biology, Biotechnology, Molecular Biology, or a related field with 2+ years of relevant experience.
Hands-on experience developing and executing complex cellular assays using primary immune cells, patient-derived samples, and cell line–based systems.
Experience working with functional immune readouts, including flow cytometry–based phenotyping and signaling assays, and cytokine measurement (ELISA/MSD/other).
Demonstrated expertise in protein-level analysis of signaling pathways, including Western blotting and related biochemical techniques used to assess pathway activation, inhibition, and mechanism of action.
Strong understanding of cell signaling pathways relevant to immune and inflammatory biology.
Proven ability to independently design experiments, troubleshoot assays, and manage multiple priorities.
Proficiency with data analysis and visualization tools (e.g., GraphPad Prism, FlowJo, Excel).
Excellent written and verbal communication skills.

Experience supporting immune pharmacology and MoA characterization in early drug discovery.
Background in inflammatory or autoimmune disease biology (IBD, RA, dermatology preferred).
Familiarity with assay validation, quantitative potency assessment and translational biomarker analysis/ identification.
Experience working in a fast-paced, innovative biotech environment.

Be part of a passionate team making a difference in biotech innovation.
Collaborative and dynamic work environment.
Hands-on experience with state-of-the-art technologies.
Opportunities for professional development and advancement.
Competitive compensation and benefits.

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