Scientist II, ASO Process Development and Manufacturing

Biogen•Cambridge, MA

About The Position

About This Role We are looking for a highly motivated and creative Scientist II to join our Oligonucleotide Chemical Development team. This role offers an exciting opportunity to contribute to the development of robust processes for synthesizing oligonucleotides. As part of this team, you will gain hands-on experience in designing and developing manufacturing processes for clinical and commercial therapeutics. You will play a pivotal role in optimizing synthesis processes, focusing on enhancing process robustness, productivity, and impurity control. Your work will have a significant impact on advancing our therapeutic capabilities, fitting into the broader mission of delivering innovative solutions to improve patient lives. Who You Are You have a passion for exploring novel scientific concepts and are eager to contribute to developing cutting-edge technologies in oligonucleotide synthesis. Your vision and dedication drive you to push the boundaries of Biogen’s scientific endeavors, ultimately impacting patient lives. You thrive in a collaborative environment and are committed to advancing innovative solutions.

Requirements

Specialization in synthetic organic chemistry with excellent synthetic skills and a deep understanding of reactivity and reaction mechanisms.
Ph.D. with 0-3 years of relevant postdoc experience.
M.S. with 4+ years of relevant experience in pharmaceutical or biotech settings.
BS with 6+ years of relevant experience in pharmaceutical or biotech settings
Ability to perform synthetic process research and development of drug candidates including conjugates and starting materials beyond platform oligonucleotides by using information from literature, conferences, seminars etc.
Knowledge in patent applications and manuscripts for publications.
Ability to work independently and collaboratively within a team environment.
Effective communication skills in both written and oral forms.

Nice To Haves

Experience in nucleoside chemistry or oligonucleotide synthesis
Experience in API synthesis process development

Responsibilities

Collaborate with development and manufacturing teams to design and conduct laboratory experiments to optimize and/or characterize the synthesis processes of oligonucleotides with an emphasis on improvement in process robustness and productivity and control of impurities.
Perform pilot-scale syntheses to produce oligonucleotide compounds for purification process development and/or preclinical studies.
Record the experimental procedures and data accurately.
Communicate research results effectively by writing research reports and presenting data in team meetings.
Engage in the CMC activities including authoring CMC section of INDs.
Manage the Contract Research Organization (CRO)
Initiate innovative research projects to improve synthesis processes.

Benefits

Medical, Dental, Vision, & Life insurances
Fitness & Wellness programs including a fitness reimbursement
Short- and Long-Term Disability insurance
A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
Up to 12 company paid holidays + 3 paid days off for Personal Significance
80 hours of sick time per calendar year
Paid Maternity and Parental Leave benefit
401(k) program participation with company matched contributions
Employee stock purchase plan
Tuition reimbursement of up to $10,000 per calendar year
Employee Resource Groups participation