Scientist II, Analytical Pathology, Enzymes and Metabolic Research Unit

Biomarin Pharmaceutical Inc. • San Rafael, CA

35d

About The Position

BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best - people with the right technical expertise and a relentless drive to solve real problems - and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we've produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. The Enzymes and Metabolic Research group is seeking a highly motivated Scientist II with a strong background in pathology, image analysis and conducting preclinical translational research evaluating potential therapeutics for severe rare genetic diseases with unmet medical needs. Applicants should have experience in basic histologic techniques, immunohistochemical and in situ hybridization assays, imaging and image analysis. Using a quantitative histological approach, this role will design and optimize algorithms to quantify signals detected using in situ hybridization, immunohistochemistry or spatial proteomic and transcriptomic approaches. In addition, this position will evaluate and implement new platform technologies. The ideal candidate is highly motivated, tech savvy, a critical thinker, and able to work both independently as well as in a team environment. In addition, the candidate should possess excellent analytical, organizational and communication skills.

Requirements

• PhD with a minimum of 3- 5 years related or post-doctoral experience; or a MS and a minimum of 8-10 years related experience; or a BA/BS and a minimum of 8-15 years related experience.
• Strong background in analytical pathology, histological techniques, database management and image analysis platforms.
• Knowledge of project management tools, methodologies and best practices.
• Excellent CRO management, budgeting and resource allocation skills.
• Demonstrated ability to work in a fast-paced, team-orientated environment with aggressive timelines.
• Ability to interact successfully with team members from a wide variety of functional areas and all levels of contribution and expertise.
• Strong communication (verbal and written) skills.

Nice To Haves

• Background in enzyme replacement therapies, lysosomal storage disorders or rare genetic metabolic disease is preferred.

Responsibilities

• Strong understanding and hands-on experience of histological techniques, including but not limited to, immunohistochemistry, in situ hybridization and spatial transcriptomics.
• Advanced microscopy and imaging skills including multiplex fluorescence imaging, confocal microscopy, live-cell imaging, laser capture microdissection, light-sheet microscopy.
• Develop novel image analysis algorithms using advanced image analysis software to quantify markers of pathology, subcellur localization and/or biodistribution of novel drug candidates.
• Lead or provide functional support for early stage project teams from exploratory through Stage -1.
• Author study plans, protocols, technical reports, and SOPs associated with the research design and methods developed to investigate the mechanism of action, efficacy, quality or safety of novel drug candidates.
• Collaborate with Business Development on efforts to identify and nominate new assets for investigation and acquisition.
• Mentor and coach junior staff on experimental design, troubleshooting, assay optimization and data interpretation.

Benefits

• This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package.
• Benefits include company-sponsored medical, dental, vision, and life insurance plans.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Industry: Chemical Manufacturing
• Education Level: Ph.D. or professional degree