Scientist I or II / Mass Spectrometry Screening

UCB • Cambridge, MA

2d • Onsite

About The Position

We are seeking a highly motivated and independent Scientist I or II / Mass Spectrometry Screening to join our Discovery Sciences team at the UCB-Boston (Cambridge) site. This role will support early-stage programs across UCB’s therapeutic areas of interest through designing, executing, and interpreting mass spec-based assays for hit discovery and hit to lead optimization. Please note that this is a lab-based position requiring you to be onsite 5 days/week.

Requirements

• MS or PhD in Analytical Chemistry, Chemistry, Biochemistry, or related discipline. Recent PhD graduates with strong hands-on AS‑MS experience are encouraged to apply
• Demonstrated expertise in mass spectrometry. Direct experience with AS/MS, MS/MS, and library screening is preferred.
• Prior knowledge of the relevant application area (e.g., discovery screening, protein–ligand interactions, small-molecule analysis)
• Strong analytical thinking, problem‑solving, and scientific communication skills

Nice To Haves

• Experience with developing and prosecuting peptide-based library screening using MS is highly preferred.
• Experience with LC–MS, HRMS, and MS/MS in the context of AS‑MS workflows
• Experience working in a discovery or industry research environment is a plus
• Publications or conference presentations in mass spectrometry or related fields.

Responsibilities

• Design, develop, and execute Affinity Selection Mass Spectrometry (AS‑MS) assays to support small-molecule and peptide screening in collaboration with discovery teams.
• Work as part of a cross‑functional team to develop and deploy mass spec-based screening strategies and communicate results to drive pipeline research programs.
• Generate large screening data sets and collaborate with Data Analytics team to leverage data for hit selection and SAR generation.
• Maintain, troubleshoot, and improve MS instruments and workflows.
• Stay current with advances in mass-spectrometry based technologies and emerging methodologies in the field.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 1,001-5,000 employees