Scientist I, Infectious Diseases

ModeX Therapeutics•Weston, MA

About The Position

ModeX Therapeutics is seeking a motivated scientist with experience in molecular biology. They will be part of a dynamic team focusing on developing innovative biotherapeutics for treating infectious diseases. The primary responsibilities of the position are to work with senior team members to design DNA constructs, produce proteins, maintain cell lines, perform biological assays, and coordinate CROs. This is an exciting opportunity to be part of a cross-functional team and contribute to the development of next-generation synthetic biotherapeutics in a fast-paced, rapidly growing biotech company with a bold vision. ModeX Therapeutics, an OPKO Health company, is the leading clinical-stage biopharmaceutical company developing unique and proprietary-multispecific therapeutics. Its MSTAR platform unites the power of multiple biologics in a single molecule to create multispecific antibodies that bind four or more targets with unprecedented versatility and potency for complex diseases. Its promising first-in-class immunology pipeline includes candidates against immune diseases, including cancer (both solid and hematologic tumors), immune impairment, as well as several of the world's most pressing viral threats. Its founding team includes globally recognized medical innovators with proven track records of delivering breakthroughs for patients. ModeX is based in Weston, Massachusetts. For more information, please visit www.modextx.com.

Requirements

PhD with 0-1+ yrs industry experience in infectious disease, virology, molecular biology, protein biochemistry, or related field.
Knowledge and hands on experience in molecular cloning, cell culture and biological assays.
Protein purification experience.
Experience working with mammalian cells and good sterile technique.
Familiarity with the production and characterization of antibodies.
Excellent written and communication skills for collaborating with team members and presenting data.
Highly adaptable to a fast-paced work environment and can efficiently prioritize tasks and manage time.

Responsibilities

Support the molecular cloning pipeline, including DNA silico analysis, codon optimization, gene fragment assembly, cloning and production of transfection grade plasmids.
Transfection, expression, and purification of proteins from mammalian cells using endotoxin free methods.
Perform in vitro biochemical and biophysical characterizations of protein candidates, including techniques like ELISA, Octet, DLS, SDS-PAGE, and Western Blot.
Production of lentiviral based pseudovirus stocks.
Test activity of antibodies in pseudovirus neutralization assays.
Help design and coordinate studies with CROs.
Proficient in independently addressing and resolving experimental problems.
Exceptional organizational, technical, and troubleshooting skills, with keen attention to detail and sterile technique.
Careful and thorough recording of experimental data using an electronic lab notebook.
Analyze data using appropriate software and statistical methods, and clear reporting of results to the team.
Work both independently and collaboratively as part of a project team.