Scientist I/II, Pre-Clinical

Lexeo Therapeutics • New York, NY

6d • $108,000 - $155,000 • Hybrid

About The Position

We are seeking a talented, dedicated, passionate and motivated individual with experience in the design and execution of pre-clinical proof-of-concept in vitro and in vivo studies of genetic medicines to join our team as Scientist I/II. The ideal candidate will have a robust background in basic and translational research and be proficient in planning and executing in vitro and in vivo pre-clinical efficacy studies. They will also be capable of managing projects, fostering collaborations with Key Opinion Leaders (KOLs) and overseeing partnerships with vendors and academic partners for pre-clinical studies. This is a highly collaborative role where the successful candidate will join a multi-disciplinary team focused on developing the next generation of cardiac genetic medicines

Requirements

• PhD degree (in life sciences or related discipline) and at least 2 years of industry or postdoc experience or MS degree with at least 4 years of relevant experience in industry or academia
• Extensive experience with mammalian cell culture including primary human cells is required, culturing of iPSCs and iPSC-derived cardiomyocytes is a plus
• Technical experience in genomics and molecular and cellular biology (NGS, PCR, qPCR, flow cytometry, Western blots, ELISA)
• Familiarity with drug discovery for genetic medicines
• Ability to multi-task and excel in a fast-paced environment
• Excellent troubleshooting, written/verbal communication and project management skills
• Proficiency with applications used for scientific data analysis (e.g., GraphPad, MS, JMP, etc)

Responsibilities

• Design and execute proof-of-concept genetic medicine studies in cell lines, primary cells, iPSC-derived cells and animal models
• Design and oversee in vitro and in vivo pre-clinical studies to evaluate the efficacy and safety of genetic medicine strategies with CROs and external partners
• Develop and execute assays for in vitro and in vivo phenotypic outcomes using next-generation sequencing (NGS), PCR, qPCR, flow cytometry, Western blots and/or ELISA
• Analyze and interpret data and present to internal and external audiences
• Contribute to the scientific efforts and develop innovative solutions by maintaining a broad understanding of the field

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree