Scientist, High Throughput Antibody Production
About The Position
Join our dynamic Waltham team within Biologics Engineering, where innovation meets dedication. As part of a global organization, we are committed to discovering and optimizing next-generation biologics across key therapeutic areas. Our mission is to push the boundaries of science and creativity, delivering life-changing medicines to patients. Are you ready to contribute to groundbreaking biologics discovery platforms and novel drug modalities that address unmet medical needs? Accountabilities As a Scientist in our Waltham, MA team, you will play a crucial role in executing well-validated SOPs for high-throughput antibody production and purification. Your focus will be on delivering microgram-to-milligram quantities of antibody therapeutics efficiently and reliably. You will manage scheduled production campaigns, ensure instrumentation readiness, perform routine QC, and compile comprehensive data packages for project teams.
Requirements
- Master’s degree with 1+ years of experience in antibody expression/purification, UPLC, or molecular biology
- Bachelor’s degree with 3+ years of experience in antibody expression/purification, UPLC, or molecular biology
- Demonstrated experience executing standardized high-throughput expression and purification workflows for antibodies or antibody-like proteins at microgram-to-milligram scale.
- Hands-on operation of liquid handlers (Hamilton or Lynx preferred) using validated methods with integrated automation platforms (Biosero/Green Button Go) a plus.
- Proficiency in mammalian cell culture (CHO and HEK293), aseptic technique, and transient expression.
- Experience with sample tracking and laboratory logistics/LIMS software; comfort with barcode-driven workflows.
- Ability to plan production runs, manage consumables, and meet deadlines in a fast-paced environment.
- Strong attention to detail, documentation rigor, and adherence to SOPs and QC acceptance criteria.
- Effective communication and collaboration across cross-functional teams.
Nice To Haves
- Working knowledge of protein purification technologies and common analytical methods (e.g., SEC-UPLC, LC-MS, SDS-PAGE, CE).
- Familiarity with lab automation scheduling software; Green Button Go preferred.
- Basic scripting for data handling (e.g., Python, Jupyter) is a plus, not required.
- Exposure to imaging or flow cytometry platforms and analysis tools (iQue, Attune, FlowJo) is beneficial for specific assays but not central to the role.
Responsibilities
- Executing well-validated SOPs for high-throughput antibody production and purification.
- Delivering microgram-to-milligram quantities of antibody therapeutics efficiently and reliably.
- Managing scheduled production campaigns.
- Ensuring instrumentation readiness.
- Performing routine QC.
- Compiling comprehensive data packages for project teams.
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Number of Employees
5,001-10,000 employees
