Scientist, Functional Genomics, Konermann Lab
About The Position
The Konermann Lab is seeking an exceptional Scientist to lead and collaborate on projects at the intersection of functional genomics and neurobiology. In this role, you will serve as experimental domain expert and apply state-of-the-art cell engineering, CRISPR screening and Perturb-seq technologies to advanced cellular model systems to decipher fundamental biological processes in neurons, microglia and other relevant cell types, provide molecular insights into the role of genetic risk factors in the progression of neurodegenerative diseases (with a focus on Alzheimer’s disease) as well as identify potential genetic modifiers to ameliorate disease progression. This position offers a unique chance for a highly motivated and curious researcher to collaborate with an interdisciplinary team of neuroscientists, computational biologists and in vivo scientists to connect novel molecular insights to potential translational applications.
Requirements
- PhD in Molecular Biology, Bioengineering, Genetics, or a related field.
- 0-3 years of post-PhD research experience (industry or academia).
- Strong hands-on experience with mammalian cell culture and molecular biology techniques (cloning, library preparation, etc.).
- Deep expertise in functional genomics, specifically with CRISPR screening technologies (pooled or arrayed) including library design, library cloning, delivery of gene editors, screen design, screen execution and screen analysis.
- Strong critical thinking and data analysis skills, with the ability to troubleshoot complex experimental protocols.
- Excellent written and verbal communication skills, with a track record of peer-reviewed publications or preprints.
- A collaborative mindset and enthusiasm for mentoring and working within a cross-functional team.
Nice To Haves
- Experience with single-cell RNA-seq and single-cell genomics technologies (e.g. 10X Genomics, Perturb-seq/CROP-seq or similar).
- Experience with live-cell microscopy, optical pooled screening and/or multiplexed proteomic readouts (e.g. CITE-seq, Olink or similar).
- Experience working with human iPSCs and differentiation procedures.
- Background in neurobiology/neurodegenerative disorders.
- Proficient in bioinformatics/data analysis of large datasets (using Python, R etc)
Responsibilities
- Collaborate with neurobiologists to implement functional genomics assays (arrayed and pooled) in human iPSC-derived neurons, microglia and multi-cellular stem cell derived brain models.
- Serve as the technical expert in the design, execution, and analysis of functional genomic screens.
- Develop and optimize novel screening assays and readouts suitable for neuronal/glial phenotypes.
- Perform cell culture, differentiation, and genome engineering of human ESC/iPSC and/or immune cell types.
- Analyze multi-omic datasets and collaborate with computational scientists to derive insightful conclusions as well as generate new testable hypotheses.
- Present findings at internal meetings and external conferences, and contribute to the preparation of high-impact manuscripts.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
Number of Employees
101-250 employees
