Scientist, Formulation Discovery

Eli Lilly and Company • Boston, MA

19h

About The Position

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Organization Overview: Verve Therapeutics, a wholly owned subsidiary of Eli Lilly & Company within Lilly Research Labs, is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines. The company’s initial three programs – VERVE-101, VERVE-102, and VERVE-201 – target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. VERVE-101 and VERVE-102 are designed to permanently turn off the PCSK9 gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE-201 is designed to permanently turn off the ANGPTL3 gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia. In 2024, Verve was named a Top Place to Work by The Boston Globe for the fourth consecutive year. Verve is headquartered in Boston, Massachusetts.

Requirements

• B.S. degree in chemical engineering, bioengineering, chemistry, pharmaceutical sciences, or another related field
• Qualified applicants must be authorized to work in the United States on a full-time basis.
• Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1

Nice To Haves

• Experience with nanomedicinal or nanoparticle formulations preferred.
• Strong problem-solving skills, and creative/innovative thinking in problem solving.
• Ability to work independently and collaboratively in very dynamic interdisciplinary team environments.
• Proven track record in working with partners/collaborators is desirable.
• Organized, diligent, and innovative self-starter who continuously seeks to improve existing laboratory methods and processes.
• Effective verbal and written communication skills; proficiency in literature search and relevant computer software skills are required.

Responsibilities

• Design and preparation of lipid nanoparticles (LNPs) for early-stage evaluation of delivery of nucleic acid payloads in cell-based and preclinical animal models.
• Characterization of LNPs through HPLC, DLS, spectroscopic techniques such as UV-Vis and fluorescence, ribogreen assays, and pKA.
• After successful screening and identification of lead LNP formulations, the candidate will have the opportunity to further streamline and advance the formulation towards clinical development.
• Design, preparation, and characterization of lipid nanoparticles for screening efficient delivery of nucleic acid payloads in preclinical animal models.
• Prepare technical reports and presentations pertaining to formulation development
• Generate/write protocols, and SOPs.
• Cross-functional collaboration
• Other duties as assigned

Benefits

• Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).
• In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level