Scientist, Discovery Toxicology

Bristol Myers Squibb•San Diego, CA

2d•Onsite

About The Position

Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. The Pharmaceutical Candidate Optimization organization at Bristol Myers Squibb is a dynamic, multi-disciplinary department that works to discover and optimize new drug candidates. We work across all therapeutic areas and all modalities (small molecules, biotherapeutics, gene and cell therapies and other novel modalities),and engage with all other R&D functions to advance new assets in the BMS portfolio. Our integrated, cross-functional teams apply deep expertise in drug metabolism, pharmacokinetics (DMPK), toxicology, pharmaceutics, and bioanalysis to identify and solve issues, discover high quality drug candidates, and enable their clinical development. Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma. Position Summary: We are seeking an innovative scientist to join the Discovery Toxicology laboratory at BMS San Diego. The Discovery Toxicology team supports the early-stage discovery of pharmaceuticals, including early risk assessment, mechanistic investigation, and risk mitigation from initial target identification through to development candidate nomination. The scientist will serve as an integral member of the Discovery Toxicology team and conduct experiments to support the progression of assets across modalities (e.g., small molecule, targeted protein degraders, antibody-drug conjugates, oligonucleotides, peptides, etc.) within the discovery portfolio. The successful candidate will be expected to explore and evaluate novel assays and laboratory techniques to expand internal capabilities and contribute to the advancement of toxicology research. A key area of research will include the development, characterization, and qualification of complex in vitro models for toxicology-related contexts of use including but not limited to organoids, spheroids, and microphysiological systems such as tissue chips. Advanced experience in primary cell culture and molecular biology is essential, and education/background in toxicology, cell biology, biomedical engineering, or a related field is required.

Requirements

Master’s with 3+ years relevant experience in industry or academic equivalent or PhD in Toxicology or other relevant discipline (e.g., Pharmacology, Biomedical Engineering, Immunology, Biology, etc.) and a general understanding of drug discovery and development is required
Proficient mammalian cell culture skills are required with experience in primary cell culture
Expertise in molecular biology techniques and assay development (e.g., ELISA, western blotting, multiplexed protein analysis, PCR, gene editing, etc.) is required
Ability to design, execute, troubleshoot, and interpret in vitro experiments and develop protocols to facilitate method sharing among scientists in Discovery Toxicology
Ability to work in a collaborative team environment
Advanced written and verbal communication skills are a must

Nice To Haves

Experience working with complex in vitro models such as organs-on-chip, 3D tissues, spheroids, organoids, etc. is desired but not essential

Responsibilities

Design, execute, troubleshoot, and interpret in vitro cell culture and molecular biology experiments
Develop and evaluate primary cell-based and/or iPSC-based complex in vitro models
Apply analytical techniques such as ELISA, PCR, CRISPR, biochemical assays, immunofluorescence, Jess, etc., for the functional evaluation of in vitro models
Author internal reports and manuscripts associated with exploratory/investigative activities in scientific journals and present research internally and at external conferences
Develop and maintain clear assay protocols and data documentation to facilitate method sharing among scientists in Discovery Toxicology
Learn to conduct analytical assays that can support broad-based mechanistic toxicology investigations
Work collaboratively with functional experts across the organization to successfully execute projects

Benefits

Health Coverage: Medical, pharmacy, dental, and vision care.
Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.
Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

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