Scientist, Chemistry

Octant Bio•Emeryville, CA

6d•$130,000 - $145,000•Onsite

About The Position

Octant is seeking a driven and curious Scientist to join the OpenADMET team. OpenADMET’s mission is to build open predictive models of safety and toxicity for small molecules to improve humanity’s ability to more reliably, cheaply, and effectively treat disease. At a high level, you’ll play a hands-on role in leveraging Octant’s Navigator platform to synthesize and analyze novel small molecules that modulate disease-relevant cellular mechanisms. Specifically, you will support the OpenADMET initiative at Octant by building libraries targeting the “avoidome” to generate high quality data to fuel machine learning model development. You will also expand our platform chemistry capabilities by pioneering novel synthetic and analytical methods. Finally, you will leverage your platform expertise to further Octant’s drug discovery efforts. This is an opportunity to revolutionize the way we build drugs.

Requirements

PhD in Organic Chemistry, Chemical Biology, or related field with 0-3 years experience post PhD as a post doctoral candidate or industry scientist
Expertise with multi step organic synthesis, purification and analysis (HPLC, LC/MS, NMR)
Familiarity with the application of LC-MS methods for proteomics or high throughput screening
Experience with laboratory automation platforms and high-throughput screening methods
Excellent problem-solving and communication skills

Nice To Haves

Experience coding for data analysis, visualization or lab automation (e.g., Python)
Familiarity with high-throughput experimentation and direct-to-biology high throughput chemistry approaches
Optional: Along with your application, please share a paper/preprint/software repo that best highlights your strengths so we can better understand work you've led. If there is nothing public, please summarize that work in a few paragraphs. We'd love to also hear about things you've been proud to build or lead outside of science.

Responsibilities

Synthesize and analyze novel small molecules that modulate disease-relevant cellular mechanisms.
Support the OpenADMET initiative at Octant by building libraries targeting the “avoidome” to generate high quality data to fuel machine learning model development.
Expand our platform chemistry capabilities by pioneering novel synthetic and analytical methods.
Leverage your platform expertise to further Octant’s drug discovery efforts.