Scientist, Cell Line Development

GlaxoSmithKline • Cambridge, MA

377d

About The Position

GSK Vaccines is seeking a highly motivated scientist to join the Mammalian Expression Technologies Center of Excellence (MET CoE) in Cambridge, MA. This role focuses on the early development of production cell lines and baseline upstream processes for recombinant protein-based vaccines. The position is integral to shaping GSK's vaccine pipeline to address unmet medical needs and accelerate global health initiatives, providing an exciting opportunity to work with a diverse group of industry experts and lead key cell line development activities.

Requirements

• PhD, MS, or BS degree in Biochemistry, Cell Biology, Molecular Biology, Bioengineering or relevant fields with 1+ (PhD), 3+ (MS), or 5+ (BS) years relevant experience within a pharmaceutical or biotech industry.
• One or more years of experience in developing early upstream manufacturing processes for engineered mammalian cell lines (CHO preferred).
• One or more years of hands-on experience with high-throughput (small-scale) bioreactors, automation, and associated data infrastructure, typically used in the manufacture and characterization of biological products.

Nice To Haves

• Proficiency with Microsoft Excel or statistical analysis software (JMP, Prism, etc.) for analyzing and presenting data.
• Ability to think critically, analytically, and demonstrate strong troubleshooting and problem-solving skills based on deductive reasoning.
• Ability to design and implement experiments with minimal technical supervision.
• Strong organizational and time management skills with the ability to prioritize and manage multiple tasks/project activities simultaneously.
• Dedicated team player with a collaborative mindset to support cross-functional knowledge sharing.
• Understanding of Quality by Design (QbD) principles and PAT framework.
• Ability to embed advanced analytics (including AI/ML) and data sciences to drive platform development and move to predictive in-silico design.
• Working understanding of US/EU regulatory requirements and working knowledge of cGMPs.

Responsibilities

• Hands-on development of commercial CHO cell lines for recombinant protein-based vaccines by harnessing the understanding of cell x molecule x process.
• Key contributor toward the design and implementation of new technologies and fit-for-purpose advanced data analytics (including AI/ML) for rapid cell line development.
• Work effectively in a team environment to interpret project results and contribute to technical discussions by effectively communicating key updates to collaborators and team members.
• Maintain accurate and detailed laboratory notebooks and electronic records (e.g., SOPs, batch records, and reports) in compliance with company policies and current regulatory requirements for accelerated CMC submissions.
• Travel to Rockville, MD (Washington DC area) for 2 to 3 months within the first year to support and ensure a smooth transition of methods and know-how to the new laboratories in Cambridge.

Benefits

• Comprehensive benefits program including health insurance, dental insurance, and vision insurance.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Industry: Chemical Manufacturing
• Education Level: Bachelor's degree