Scientist – Cardiometabolic Disorders (Discovery)

Amgen • Thousand Oaks, CA

1d

About The Position

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Scientist Cardiometabolic Disorders (Discovery) A Scientist at Amgen is responsible for designing and conducting experiments, analyzing results, and interpreting data. They prepare technical reports, summaries, and protocols and present study results at team meetings. They also assist in maintaining lab equipment, troubleshooting issues, and ensuring safety protocols are adhered to. What you will do Let’s do this. Let’s change the world. In this vital role you will join our Cardiometabolic Disorders team in Thousand Oaks, California to uncover novel target and disease mechanisms and advance therapeutic programs. The team focuses on developing therapeutics and elucidating disease biology for some of the most debilitating cardiometabolic disorders plaguing society. The individual will join a team of dedicated scientists committed to finding cures for these diseases to help patients. A well-suited applicant will have great molecular and cell biology laboratory skills, deep scientific curiosity, and strong interpersonal and communication skills to thrive in a collaborative environment. The successful candidate will be responsible for the development, optimization, and implementation of in vitro and ex vivo mechanism-of-action and therapeutic validation studies that advance Amgen’s cardiometabolic disorders early pipeline. This is a permanent role that offers potential for advancement and career development. If you have a passion for science and want to be part of an organization discovering new medicines that will impact patients’ lives, we invite you to join us!

Requirements

• Doctorate Degree (PhD) or Master’s Degree with 3+ years of experience or Bachelor’s Degree with 5+ years of experience.

Nice To Haves

• Demonstrated expertise in molecular and cell biology laboratory techniques, especially as they pertain to cardiometabolic disease biology.
• Expertise working with both immortalized cell lines and primary cells.
• Extensive experience in cell-based, molecular and biochemical techniques, including live cell imaging and image processing, RNA isolation/qPCR, protein immunoprecipitation, immunoblotting, ELISA and flow cytometry.
• Hands-on expertise with cell line engineering technologies, including CRISPR and lentivirus-based stable cell line generation.
• Demonstrated experience analyzing and interpreting complex datasets.
• Excellent written and oral communication skills.
• A strong record of high-impact publications in this field.
• Demonstrated ability to prioritize tasks and efficiently manage multiple projects.
• Ability to work independently, problem-solve, and meet deadlines in a collaborative environment.

Responsibilities

• Conduct laboratory-based experiments to deepen our understanding of cardiometabolic disease biology.
• Develop and implement assays to evaluate potential therapeutics to advance the pre-clinical pipeline.
• Use of laboratory techniques such as: cell culture (including primary cells), transfection and lentiviral transduction, CRISPR-based cell line engineering, ELISA, immunofluorescence and live cell imaging, SDS-PAGE and immunoblotting, molecular biology techniques including RNA and protein analysis.
• Organize, analyze, critically interpret, and properly document experimental design and data.
• Present research findings effectively in both written and oral formats for internal teams and external collaborators.
• Keep up to date on current literature and knowledge in the field to apply to experimental design and analysis.

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees