Scientist 3, Discovery Oncology

Roche • South San Francisco, CA

5d • Onsite

About The Position

The Department of Discovery Oncology at Genentech is excited to announce an opportunity for a lab-based Scientist with a strong interdisciplinary background. This position will be part of the RAS-MAPK Signaling and Intervention Strategies Laboratory, which focuses on understanding oncogenic signaling mechanisms and developing novel therapeutic strategies targeting the Ras/MAPK pathway. The ideal candidate will have deep expertise in cell biology and oncogenic signaling pathways. This position will focus on discovering new targets and mechanisms of action in oncogenic signaling. The successful candidate will integrate molecular biology, cell biology, and protein biochemistry to investigate differences in signaling mechanisms in normal and cancer cells. Working closely with drug discovery project teams, translational medicine, and clinical development teams, you will help identify new therapeutic hypotheses and advance discovery and development of transformative medicines. This role offers a unique opportunity to make a significant impact at the forefront of research and drug discovery at Genentech.

Requirements

• Ph.D. in Biochemistry, Cell Biology, or a closely related field.
• Your record should reflect sustained high-impact publications and/or patents, and substantial progress on projects that have deepened our understanding of cancer biology.
• Demonstrated expertise in cell biology techniques including transfection and stable cell line generation, organoid culture, CRISPR/Cas9 gene editing and screening
• Demonstrated expertise in molecular biology techniques including IP, qPCR, western blots, FACS, IHC, RNAseq, ChIP-seq and analysis; cancer research, and biochemistry.
• A fearless scientist who tackles difficult problems, continuously develops new skills, and applies any technique or method necessary to advance our understanding of human cancers and discover new intervention strategies.

Nice To Haves

• Postdoctoral experience is preferred, but not essential.
• Experience in the RAS-MAPK signaling pathway and induced proximity is a plus.
• Experience with or interest in leveraging AI/ML to accelerate research is a plus.

Responsibilities

• Work closely with internal experts across computational, research biology, and drug discovery disciplines to develop hypotheses and model systems that drive innovative therapeutic strategies.
• Perform cell biology and biochemistry experiments to characterize drug-like molecules and investigate their mechanisms of action.
• Generate high-quality, original research that advances our understanding of cancer biology as well as contributing to the development of new therapies for oncologic indications.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees