Scientist 1/Scientist 2, Advanced Technologies

Personalis, Inc•Fremont, CA

3d•$110,000 - $150,000•Onsite

About The Position

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care throughout the patient journey. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Summary: Personalis is a genome-scale diagnostics company with a mission to pioneer genome guided medicine. Our priority is to obtain the most accurate genetic data from each sample, and then to draw the most reliable medically-focused conclusions from these. Our tests are based on whole human genome and exome sequencing, conducted in our state-of-the art laboratory. We analyze results utilizing proprietary databases, advanced human reference sequences, and sophisticated algorithms. You will work with a world-class, dynamic team of scientists, software engineers, assay developers, product managers, and clients applying our cutting-edge cancer and immuno-oncology solutions. As a Scientist 1 or Scientist 2, you will leverage your expertise in molecular biology and NGS workflows to develop new protocols, optimize new and existing methods, as well as plan, execute, analyze, and interpret results from development projects and validation studies. You should be an energetic and hands-on individual who has the technical background to identify issues, provide technical insights and find effective solutions. Your work will contribute to a new generation of genomics-based precision medicine products in immuno-oncology and cancer clinical trials, diagnostics, and therapeutics being used by pharma, biotech, hospitals and clinicians.

Requirements

Scientist 1: PhD with 0-2 years of experience or MS with a minimum of 6 years of experience or BS with a minimum of 8 years of experience
Scientist 2: PhD with a minimal 2+ years of experience or MS with a minimum of 8 years of experience or BS with a minimum of 10 years of experience
Hands-on experience with NGS and DNA/RNA manipulations including extractions, library preparations, purifications, quantifications (Qubit and Nanodrop), PCR/qPCR/ddPCR, electrophoretic QC (Bioanalyzer and Tapestation), enzymatic assays.
Basic NGS data analysis knowledge and familiar using tools for data visualization.
Passion for exploring new technologies and thinking creativity to solve problems
Strong written and verbal communication skills
Excellent organizational skills, with a proven ability to troubleshoot complex technical issues.
Flexibility, multitasking, teamwork and self-initiative are required to support simultaneous projects.
Strong desire to work in a demanding, high-energy, hands-on startup environment.

Nice To Haves

Experience in biotech, clinical labs, lab automation, LIMS and/or bioinformatics is highly desired.

Responsibilities

Apply advanced molecular biology techniques to develop and perform feasibility experiments to support early research and new product development.
Design, execute and document development, equivalency, verification and validation studies.
Stay current with the latest developments in NGS and molecular diagnostics, proactively determining which technologies can be leveraged to enhance and expand Personalis’ product portfolio.
Identify problems in current processes and come up with troubleshooting approaches and solutions
Work cross functionally with the bioinformatics teams to plan experiments and analysis to validate novel procedures and analytics
Collaborate with the Product Development, Tech Transfer and Automation teams for the development and implementation of new products
Communicate complex data in a clear and concise manner to a diverse audience
Foster a highly collaborative and dynamic working environment through effective, two-way communication
Support documentation efforts for laboratory procedures.
Support and ensure compliance with all department and company policies and procedures