Scientist 1 Bioconjugation Chemistry (TEMPORARY)

Biomarin Pharmaceutical • San Rafael, CA

279d • $51 - $75

About The Position

From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases.

Requirements

• Extensive experience with different bioconjugation strategies and optimizations thereof for polymers, proteins/peptides, lipids, oligonucleotides and other biomolecules
• In-depth experience in bioconjugate purification techniques including various liquid chromatography methods (e.g. RP, IEX, SEC, HIC, affinity, FPLC) and membrane filtrations (e.g. TFF)
• Prior experience in biochemistry techniques and analytical methods such as SEC-MALs, LCMS, SPR/BLI, ELISA, SDS-PAGE, enzyme activity assays, etc.
• Willingness to learn new bioconjugation chemistries or delivery modalities and work across diverse therapeutic areas to develop protein therapeutics.
• Strong analytical mindset and chemistry problem-solving with creative thinking
• The position requires organization skills, attention to detail, self-motivation, and strong teamwork in a fast-paced setting

Nice To Haves

• A record of accomplishments/publications in relevant scientific discipline and some hands-on experience in oligonucleotide delivery is preferred but not required.

Responsibilities

• Synthesis, optimization, and high-quality delivery of various polymer, protein/peptide, and lipidated bioconjugates in support of discovery and development of novel therapeutics, with an emphasis on oligonucleotides
• Development and implementation of new linker chemistries/spacers and bioconjugation methods for targeted drug delivery
• Leveraging appropriate purification and analytical characterization approaches for QC and validation
• Collaboration with internal and external partners for material transfer to support in vitro and in vivo POC experiments; assemble data packages and maintain quality control documentation through Benchling for final product delivery.
• Effectively partner with cross-functional teams, sharing insights, troubleshooting issues, and driving science forward from the bench
• Serve independently as bioconjugation technical lead and subject matter expert for internal and external project communications
• Perform data analysis, interpret, and present results during internal and external meetings; attend and participate in scientific proceedings.
• Prepare and optimize chemistry SOPs
• Participate and present data and share responsibility for project milestones

Benefits

• A discretionary bonus and/or long-term incentive units may be provided as part of the compensation package, in addition to the full range of medical, financial, and/or other benefits, dependent on the level and position offered.

What This Job Offers

• Career Level: Entry Level
• Industry: Chemical Manufacturing
• Education Level: Ph.D. or professional degree