Scientific Director, Global Medical Affairs - ATTR

Alnylam Pharmaceuticals • Cambridge, MA

1d

About The Position

The Scientific Director, Global Medical Affairs – ATTR serves as a global scientific subject matter expert supporting the ATTR franchise, with a primary focus on scientific content generation and written scientific outputs. This role reports to the VP, Medical Affairs, TTR and works in close partnership with Global Medical Leads across ATTR assets (e.g., Vutrisiran, Nucresiran).
The role will contribute deep scientific expertise to publications strategy, investigator‑initiated studies (IIS), research collaborations, post‑hoc analyses, Phase 4 activities, and business development due diligence, with a strong emphasis on hands-on writing, protocol development, and scientific review.
The role supports increasing demand for high‑quality scientific content and evidence generation across the ATTR franchise and will function as a core internal SME supporting cross‑functional teams.

Requirements

• PharmD, PhD or MD
• 3-5+ years of relevant experience within the pharmaceutical or biotechnology industry.
• Demonstrated primary authorship and substantial contribution to peer‑reviewed publications.
• Strong experience in medical, scientific, and grant writing (e.g., research proposals, manuscripts) and reviewing or developing clinical or post‑marketing study protocols.
• Deep interest in and aptitude for written scientific work; this role emphasizes writing over presenting.
• Ability to critically analyze data and translate complex science into clear written narratives.

Nice To Haves

• Experience in cardiovascular, renal, metabolic, or ATTR disease areas strongly preferred.
• Prior exposure to BD due diligence or structured scientific evaluations strongly preferred.

Responsibilities

• Serve as a scientific SME contributing to global publication strategy, planning, and execution.
• Draft, review, and critically edit scientific manuscripts, abstracts, posters, slide decks, and congress materials.
• Provide scientific leadership on data interpretation and scientific storytelling, ensuring accuracy, clarity, and alignment with the overall evidence strategy.
• Support development, review, and execution of the integrated evidence generation plan across the ATTR franchise.
• Support IIS, Research Collaboration, Phase 4, post-marketing, post-hoc analyses, real-world evidence activities, including scientific review, study and analyses design, feasibility assessment, data interpretation, and ongoing oversight.
• Lead protocol development and review across evidence generation activities, with a focus on scientific rigor and relevance.
• Collaborate closely with Global Medical Leads, Publications and Scientific Communications, Clinical Research, Regulatory, HEOR, and Commercial partners to ensure alignment and scientific integrity.
• Support cross‑functional deep dives led by Value Evidence Strategy teams, synthesizing scientific and clinical data into clear, written outputs.
• Provide scientific input into business development and licensing (BD&L) due diligence, including literature reviews, data gap assessments, and scientific risk evaluation.
• Contribute to internal briefing documents, scientific summaries, and strategic analyses to inform senior leadership decision‑making.
• Serve as a trusted internal scientific reviewer for medical materials, protocols, and external‑facing scientific content.
• Ensure all activities adhere to medical governance, compliance, and ethical standards.

Benefits

• We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match.
• Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks.
• We also offer generous family resources and leave.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree
• Number of Employees: 501-1,000 employees