Scientific Associate Director - PKDM (Small Molecule ADME)

Amgen • Thousand Oaks, CA

106d • $198,813 - $258,156 • Hybrid

About The Position

Join Amgen's Mission of Serving Patients. At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Requirements

• Doctorate degree PhD OR PharmD OR MD and 4 years of directly related experience, or a Master's degree and 7 years of directly related experience, or a Bachelor's degree and 9 years of directly related experience.

Nice To Haves

• PhD in Pharmacokinetics, Pharmaceutical Sciences, Engineering, or related fields with equivalent professional degrees and 10+ years of experience in the Biotechnology/Pharmaceutical Industry.
• Solid technical experience with the application of small molecule in vitro/in vivo ADME and pharmacokinetics fundamentals to drug discovery projects.
• Ability to drive the progression of small molecule discovery and development within project teams.
• Establish small molecule biotransformation and ADME workflows for PKDM scientists.
• Expertise with in vitro ADME, in vivo ADME, PK/PD or PBPK.
• Experience in supporting preclinical components of regulatory documentation.
• Excellent interpersonal, technical, and communication skills to lead cross-functional teams.
• Past experience as a laboratory scientist in a pharma or biotech environment.
• Record of scientific contributions through peer-reviewed articles and external presentations.

Responsibilities

• Oversee biotransformation activities and serve as a project team representative focused on small molecule programs.
• Characterize the absorption, distribution, metabolism, excretion (ADME) and pharmacokinetic (PK) properties of small molecule therapeutic drug candidates.
• Serve as a subject matter expert of small molecule biotransformation and lead biotransformation activities to support the programs.
• Develop strategies to reduce/mitigate risks due to metabolism.
• Leverage current biotransformation knowledge and develop/implement novel tools to support biotransformation activities.
• Collaborate with scientists across the PKDM scientific community.
• Plan and execute mechanistic ADME/PK analyses to optimize dose selection and preclinical study designs.
• Contribute to the analysis of pre-clinical ADME and PK data for IND and NDA filings.
• Build close relationships with partner functions and therapeutic areas.

Benefits

• Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions.
• Group medical, dental and vision coverage.
• Life and disability insurance.
• Flexible spending accounts.
• Discretionary annual bonus program.
• Stock-based long-term incentives.
• Award-winning time-off plans.
• Flexible work models, including remote and hybrid work arrangements.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Chemical Manufacturing
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees