Research Specialist – Metabolic Sensor Design
About The Position
The CombinAItorial Sensor Design project is part of HHMI’s AI for Science Initiative ( ai.hhmi.org ) and combines high-throughput optical pooled screening with advanced machine learning to engineer genetically encoded fluorescent biosensors faster and more effectively than ever before. These biosensors enable researchers to visualize metabolic and other cellular processes at single-cell, high spatiotemporal resolution. By integrating protein engineering, AI-driven directed evolution, fluorescence lifetime imaging, and in situ sequencing, our team is building a generalist biosensor optimization platform that will transform the pace and scope of biosensor development and make custom sensor engineering accessible to the broader scientific community. We are looking for a Research Specialist to help with most aspects of the project and help lead the laboratory efforts.
Requirements
- Ph.D. in molecular biology, bioengineering, biophysics, or related field.
- Strong hands-on experience with mammalian cell culture and fluorescence microscopy.
- Demonstrated ability to design, troubleshoot, and optimize complex experimental workflows.
- Familiarity with high-throughput screening methods and/or in situ sequencing.
- Excellent organizational, problem-solving, and communication skills.
Nice To Haves
- Experience with fluorescence lifetime imaging (FLIM) and image analysis pipelines (preferred).
- Background in protein engineering or biosensor development (preferred).
- Experience collaborating with computational or machine learning teams (preferred).
Responsibilities
- Plan, coordinate, and execute pooled optical screening experiments for biosensor libraries.
- Design and clone DNA libraries of protein variants
- Perform and oversee cell culture, transfection, sample preparation, and assay execution.
- Operate and maintain fluorescence microscopy systems, including FLIM.
- Work closely with AI and data analysis teams to ensure data quality, data annotation, and data transfer.
- Optimize workflows to improve throughput, reproducibility, and data quality.
- May supervise and mentor a research technician, assisting in experimental execution.
- Maintain accurate records of experiments, results, and protocol modifications.
Benefits
- A competitive compensation package, with comprehensive health and welfare benefits.
- A supportive team environment that promotes collaboration and knowledge sharing.
- The opportunity to engage with world-class researchers, software engineers and AI/ML experts, contribute to impactful science, and be part of a dynamic community committed to advancing humanity’s understanding of fundamental scientific questions.
- Amenities that enhance work-life balance such as on-site childcare, free gyms, available on-campus housing, social and dining spaces, and convenient shuttle bus service to Janelia from the Washington D.C. metro area.
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
Number of Employees
5,001-10,000 employees
