Research Scientist

Guidehouse•Bethesda, MD

11d•$85,000 - $141,000•Onsite

About The Position

We are currently searching for a Research Scientist to provide support services to satisfy the overall operational objectives of the within the National Institutes of Health. This is a full-time, on-site opportunity in Bethesda, MD. Continuously optimize and implement protocols to enhance the differentiation of human induced pluripotent stem cells (iPSCs) into engraftable hematopoietic stem cells (HSCs). Conduct experiments to ectopically activate master transcription factors that are crucial for directing cell lineage determination, ensuring that the iPSCs differentiate into the desired cell type. Investigate and apply inhibitors of key epigenetic regulators during the early stages of differentiation to enhance the developmental pathway towards HSCs. Optimize the ectopic expression of homing receptors, with a focus on the CXCR4 chemokine receptor, to improve the homing efficiency and survival of HSCs post-transplantation. Analyze experimental data, maintain detailed records of experiments, and prepare reports or presentations summarizing findings and progress in refining the differentiation platform. Work collaboratively with other researchers and team members to integrate findings and refine strategies, ensuring alignment with overall research goals. Contribute to the identification of learning needs for the CMTB environment and provide learning opportunities for others. Recommend and implement approaches and solutions to problems that may arise. Collaborate with experts to analyze and report data as applicable. Draft manuscripts for publication in scientific journals. Present findings at scientific meetings.

Requirements

Ph.D. and/or M.D.
At least four (4) years of biology related research
Proficient in microbiology techniques, including media preparation, bacteria cultivation, and bioreactor setup
Experience in enzyme production for industrial applications, demonstrating expertise in bioprocess engineering
Expertise in quantitative and qualitative research and analytic methods

Nice To Haves

Experience with tools such as SAS and R is preferred
Strong oral and written communication skills
Be able to work independently and as part of a team
Strong time management and organizational skills

Responsibilities

Continuously optimize and implement protocols to enhance the differentiation of human induced pluripotent stem cells (iPSCs) into engraftable hematopoietic stem cells (HSCs)
Conduct experiments to ectopically activate master transcription factors that are crucial for directing cell lineage determination, ensuring that the iPSCs differentiate into the desired cell type
Investigate and apply inhibitors of key epigenetic regulators during the early stages of differentiation to enhance the developmental pathway towards HSCs
Optimize the ectopic expression of homing receptors, with a focus on the CXCR4 chemokine receptor, to improve the homing efficiency and survival of HSCs post-transplantation
Analyze experimental data, maintain detailed records of experiments, and prepare reports or presentations summarizing findings and progress in refining the differentiation platform
Work collaboratively with other researchers and team members to integrate findings and refine strategies, ensuring alignment with overall research goals
Contribute to the identification of learning needs for the CMTB environment and provide learning opportunities for others
Recommend and implement approaches and solutions to problems that may arise
Collaborate with experts to analyze and report data as applicable
Draft manuscripts for publication in scientific journals
Present findings at scientific meetings

Benefits

Medical, Rx, Dental & Vision Insurance
Personal and Family Sick Time & Company Paid Holidays
Parental Leave
401(k) Retirement Plan
Group Term Life and Travel Assistance
Voluntary Life and AD&D Insurance
Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
Transit and Parking Commuter Benefits
Short-Term & Long-Term Disability
Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
Employee Referral Program
Corporate Sponsored Events & Community Outreach
Care.com annual membership
Employee Assistance Program
Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
Position may be eligible for a discretionary variable incentive bonus