Research Scientist

Takeda•Boston, MA

21h

About The Position

Takeda Development Center Americas, Inc. is seeking a Research Scientist with the following duties: Contribute to discovery projects by independently designing and developing well-defined mechanistic experiments and projects within oncology immunotherapy research focusing on leveraging Vd1 T-cells as cancer treatment. Lead from the lab to advance novel and differentiated products toward clinical milestones, by working collaboratively with internal cross-functional teams and external partners. Design, execute, and interpret functional in vitro, and ex vivo assays to understand the therapeutic mechanism-of-action and play an active role in subsequent scientific discussions to drive decisions around Vd1 T-cells as possible cancer therapy. Propose novel projects based on internal results, external partners, and published reports and demonstrate leadership through effective communication of study plans/value, and research results. Actively participate with the team to help isolate VD1 cells from blood. Tutor less experienced operators in complex procedures such as large scale Vd1 isolation from blood. Use immune cell characterization and function assessments, such as multi-color flow immunophenotyping, multiplex cytokine measurement, cytotoxicity assay, and other molecular based assays and cell-based functionality assays. Contribute to evaluation of novel engagers for Vd1 T-cells in in vitro and ex vivo model systems. Contribute to development of new assays and strategies to determine Vd1 T-cells functionality and biology to improve the efficiency of tumor control of Vd1 T-cells in presence of Cell Engagers. Collaborate with other departments to meet deadlines and generate data crucial for the programs in execution. Contribute to the writing of relevant research reports to be included in regulatory filings. Prepare and present comprehensive technical or project reports and formal presentations and posters to full range of internal/external audiences. Maintain laboratory notebooks and keep in compliance with Takeda policies; up to 20% remote work allowed.

Requirements

PhD degree in Biology, Cancer Studies, or related field plus 3 years related experience.
Prior experience must include: Isolate, culture and expand Vd1 gamma delta T cells; Design and execute in vitro/ex vivo assays of Vd1 cell function, including cytotoxicity, survival, and proliferation; Analyze experimental data and determine the relevance of results based on background knowledge of Vd1 gamma delta cell biology; Contribute to evaluation of novel immunotherapy products based on Vd1 gamma delta cell biology; Experience with gene engineering of Vd1 cells.

Responsibilities

Contribute to discovery projects by independently designing and developing well-defined mechanistic experiments and projects within oncology immunotherapy research focusing on leveraging Vd1 T-cells as cancer treatment.
Lead from the lab to advance novel and differentiated products toward clinical milestones, by working collaboratively with internal cross-functional teams and external partners.
Design, execute, and interpret functional in vitro, and ex vivo assays to understand the therapeutic mechanism-of-action and play an active role in subsequent scientific discussions to drive decisions around Vd1 T-cells as possible cancer therapy.
Propose novel projects based on internal results, external partners, and published reports and demonstrate leadership through effective communication of study plans/value, and research results.
Actively participate with the team to help isolate VD1 cells from blood.
Tutor less experienced operators in complex procedures such as large scale Vd1 isolation from blood.
Use immune cell characterization and function assessments, such as multi-color flow immunophenotyping, multiplex cytokine measurement, cytotoxicity assay, and other molecular based assays and cell-based functionality assays.
Contribute to evaluation of novel engagers for Vd1 T-cells in in vitro and ex vivo model systems.
Contribute to development of new assays and strategies to determine Vd1 T-cells functionality and biology to improve the efficiency of tumor control of Vd1 T-cells in presence of Cell Engagers.
Collaborate with other departments to meet deadlines and generate data crucial for the programs in execution.
Contribute to the writing of relevant research reports to be included in regulatory filings.
Prepare and present comprehensive technical or project reports and formal presentations and posters to full range of internal/external audiences.
Maintain laboratory notebooks and keep in compliance with Takeda policies