Research Scientist, Neuroscience

Hopewell Therapeutics • Woburn, MA

275d

About The Position

Hopewell Therapeutics is discovering, synthesizing, and developing the next generation of tissue-targeted lipid nanoparticles (ttLNPs) to bring genomic medicines to patients. We're pursuing opportunities to redefine the non-viral delivery space for novel genomic medicines by designing systemically administered LNPs to specifically target extrahepatic tissues and cells throughout the body. Hopewell has built a robust intellectual property portfolio with an expansive library of ionizable lipids and has established partnerships with several industry-leading companies. We're developing our own internal pipeline, initially targeting diseases of the lung, while concurrently exploring the potential of our ttLNP platform for patients with unmet needs in oncology, infectious diseases, rare genetic diseases, and neurological disorders.

Requirements

• Ph.D. with 1-3 years experience in neuroscience or neurobiology with animal handling and brain histology experience.
• Hands-on experience working with brain tissue dissection, histology (IF, FISH), imaging, and protein characterization.
• Working knowledge of organ physiology and cell biology in the mammalian CNS.
• Considerable experience in systematic or local injection, brain and tissue collection, molecular analysis, and downstream analysis (RT-qPCR, western blot, ELISA, bDNA quantification and IHC).
• Ability to work in the lab independently and in collaborative efforts with internal in vitro/ex vivo and in vivo groups, as well as external contractors (CROs, academics).
• Well-organized, detail-oriented, and results-driven with multi-tasking skills.
• Authorized to work in the U.S.

Responsibilities

• Designing, planning, and executing animal experiments to support the development of LNP delivery with various cargoes crossing the blood-brain barrier (BBB) via systemic injection.
• Working with an internal team and external CROs for downstream analysis, including biomedical imaging, pathology, and bioanalytical analysis.
• Conducting studies that include small animal brain characterization, biodistribution, disease model development, drug efficacy, and toxicology-like studies in neurology.
• Providing an opportunity for growth and exposure to cutting-edge research projects.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Industry: Chemical Manufacturing
• Education Level: Ph.D. or professional degree
• Number of Employees: 11-50 employees