Research Scientist/Engr 4
About The Position
Field of research: Single particle cryo-electron microscopy and X-ray crystallization of viral glycoproteins, immunogen design, virology, biochemistry and biophysics. Purpose of the Research Project(s): The goal of our research is to develop vaccines and therapeutics targeting human pathogens. Duties and Responsibilities: 20% Structure-based and machine-learning immunogen design for protein subunit and mRNA vaccines based on viral surface glycoproteins (construct design, recombinant expression in mammalian cells, purification, and stability assays), 20% Characterize protein antigenicity (binding assays using ELISAs, SPR and biolayer interferometry to evaluate binding kinetics and affinity of antibodies or designed proteins), 15% Perform structural studies (high-throughput cryo-electron microscopy of subunit vaccines as well as of complexes between viral glycoproteins and monoclonal and polyclonal antibodies as well as X-ray crystallography), 10% Design and execution of virology assays, 10% Analysis of the data to help determining the research strategy, 10% Lead projects and/or major project tasks, 10% Interactions with collaborators within our network and writing of manuscripts for publication 5% Provide guidance and direction to project staff, students and postdocs
Requirements
- Master's Degree in Biochemistry or related field and four years 4 years of experience in related field like: Cryo-electron microscopy, virology assays (pseudotyped virus generation, cellular entry and neutralization assays), protein expression in mammalian cells and purification
- Equivalent education and/or experience may substitute for minimum qualifications except when there are legal requirements, such as a license, certification, and/or registration.
Nice To Haves
- Expertise in protein and vaccine design, experience in high throughput automation using Beckman Biomek.
Responsibilities
- Structure-based and machine-learning immunogen design for protein subunit and mRNA vaccines based on viral surface glycoproteins (construct design, recombinant expression in mammalian cells, purification, and stability assays)
- Characterize protein antigenicity (binding assays using ELISAs, SPR and biolayer interferometry to evaluate binding kinetics and affinity of antibodies or designed proteins)
- Perform structural studies (high-throughput cryo-electron microscopy of subunit vaccines as well as of complexes between viral glycoproteins and monoclonal and polyclonal antibodies as well as X-ray crystallography)
- Design and execution of virology assays
- Analysis of the data to help determining the research strategy
- Lead projects and/or major project tasks
- Interactions with collaborators within our network and writing of manuscripts for publication
- Provide guidance and direction to project staff, students and postdocs
Benefits
- For information about benefits for this position, visit https://www.washington.edu/jobs/benefits-for-uw-staff/
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
