The Miriam Kim Lab studies methods to manipulate immune cells for treatment of hematologic malignancies. We work at the intersection of hematopoiesis, immunology, cancer biology, stem cell biology, and gene engineering. We are seeking motivated individuals to assist with studies investigating the optimal host environment to support chimeric antigen receptor (CAR) T cell therapy. CAR T cells are genetically engineered immune cells that are used to treat patients with hematologic malignancies such as leukemia, lymphoma and multiple myeloma. While CAR T cell therapy has demonstrated impressive success, many patients do not benefit from treatment, and so we are actively looking for ways to improve outcomes. Candidates with the ability to read scientific papers and synthesize information will be prioritized. The candidate will be given opportunities to attend scientific conferences, present at internal and external forums, review and write manuscripts, and/or other career development activities as appropriate to career goals. The ideal candidate will possess intrinsic motivation to conduct innovative and impactful research. A growth mindset and ability to learn new concepts and skills is essential. Routine laboratory techniques in our lab include: Isolation of primary immune cells from human and mouse samples, including monocytes, T cells, B cells, NK cells, and hematopoietic stem cells. Genetic manipulation of immune cells using lentivirus, retrovirus, and/or CRISPR/Cas9- based gene editing. Flow cytometry including sample preparation, acquisition and data analysis. Mouse husbandry including measuring weights, peripheral blood collection, intraperitoneal and intravenous injections.
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Education Level
Bachelor's degree