The Rossoll Lab at Mayo Clinic Florida is recruiting a Postdoctoral Fellow to join an NIH-funded project exploring the molecular chaperone functions of nuclear-import receptor proteins (importins) in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Our goal is to understand how importin act as chaperons to regulate TDP-43 phase behavior, nuclear import, and toxicity, and how these mechanisms can be harnessed to design therapeutic strategies for TDP-43 proteinopathies. We use a multidisciplinary approach combining molecular and cell biology, advanced fluorescence microscopy, proteomics, and mouse models of neurodegenerative disease to uncover how importin-mediated pathways maintain neuronal proteostasis. The position offers an opportunity to work in a highly interactive neuroscience community at Mayo Clinic Florida, with access to world-class facilities and other resources, including the brain bank. A Research Fellow position in Life Sciences (LS) will require knowledge of either clinical-based research or laboratory-based research often obtained from a postdoctoral program. A Research Fellow at Mayo Clinic is a temporary position intended to provide training and education in research. Individuals will train in the research program of a Mayo Clinic principal investigator. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants. Proof of English proficiency is required for J-1 Short-Term Scholars, Research Scholars, Professors, Specialists, and Student Interns sponsored by Mayo Clinic. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at Mayo Clinic or elsewhere.
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Job Type
Full-time
Career Level
Entry Level
Industry
Hospitals
Education Level
Ph.D. or professional degree
Number of Employees
5,001-10,000 employees