Research Fellow In Cilia Biology, Cardiac Development and Zebrafish Genetics at the MGH Cardiovascular Research Center's Yuan Lab

Mass General Brigham•Boston, MA

6d•Hybrid

About The Position

The laboratory of Dr. Shiaulou Yuan at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) is seeking highly motivated candidates for a full-time postdoctoral research fellow position. We are a multidisciplinary group of biologists, biophysicists, and microscopists who aim to understand how fluid flows and biophysical forces shape the developing heart and how these mechanisms underlie cardiac disease pathogenesis when gone awry. Specifically, we seek to illuminate how the cilium, a hair-like structure found on most cells in the human body, acts as an “antenna” to sense and translate extracellular signals into molecular processes that sculpt the early heart (Djenoune, Mahamdeh et al., Science, 2023). The penultimate goal of our research is to advance our understanding of cardiac development and diseases by combining state-of-the-art approaches from developmental biology, cell biology, genetics, biophysics, and advanced microscopy in zebrafish animal models and human stem cells. This position offers excellent opportunities to work in a highly collaborative and multi-disciplinary biomedical atmosphere, interact with distinguished scientists, physicians and physician-scientists at MGH-Harvard, and become a valued member of a collegial and growing research team. As a member of Harvard University, Massachusetts General Hospital, Mass General Brigham, and the Boston scientific community, the candidate will be immersed in a rich environment for zebrafish genetics, cardiovascular biology, cilia signaling, molecular biology, and imaging technologies.

Requirements

a strong background working with zebrafish
a PhD, MD, MD/PhD or equivalent doctoral degree in a relevant field
prior training in zebrafish husbandry and colony management, embryo micro-injection, embryo micro-dissection, confocal or light sheet microscopy, live cell imaging, quantitative image analysis, immunofluorescence, in situ hybridization, molecular cloning, CRISPR-Cas9 gene editing, recombinant protein, and/or human stem cell culture techniques
a passion for developmental biology, cell biology, cardiovascular biology, and microscopy
the ability to work independently and also as part of a team
excellent written and verbal communication skills
a strong work ethic and superb attention to details
exceptional technical and experimental skills