Research Associate/Sr Research Associate: In vivo Preclinical Research
About The Position
Research Associate/Sr Research Associate: In vivo Preclinical Research Morgan Hill, CA Description Aragen Bioscience is a leading contract research organization focused on accelerating product development. Aragen’s offerings include an entire portfolio of preclinical research services including cell-based assays and in vivo models of disease. We offer clients high quality service and superior R&D partnerships. Position Overview: Research Associates / Senior Research Associates will be responsible for primarily conducting in vivo experiments to evaluate efficacy of client test compounds across various rodent models with a secondary role in supporting in vitro / ex vivo lab work and aiding in staff distributed duties to support daily lab and vivarium operations. A successful candidate will have hands-on experience with in vivo animal studies and working knowledge of in vitro laboratory techniques to support in vivo studies, such as tissue culture, RNA/DNA processing, and ELISA/Western Blot. Candidates will work closely with multidisciplinary teams to support various client and internal projects.
Requirements
- BA/BS or MS in Biology, Immunology, Biomedical Sciences, Microbiology, Virology, Pharmaceutical Sciences, Pharmacology or a related discipline
- Two or more years of laboratory experience utilizing techniques or methods required by the position or an equivalent combination of education and experience in an academic lab environment
- Recent post graduates with a desire to expand their skill set are encouraged to apply
- Must be comfortable working with rodents and animal derived tissues or fluids
- Adept at using automated instrumentation for analysis (e.g. IDEXX or HESKA machines)
- Openness to learning new methods and skills for shifting research needs based on clients
- General understanding of data analysis techniques and use of software (e.g. Microsoft Excel and Graph Pad Prism)
- Excellent organizational skills with attention to detail and ability to prioritize tasks to meet deadlines
- Strong written/verbal communication skills for assisting with writing reports, presentations, and client interactions
- Some evening and weekend/holiday hours are required
Nice To Haves
- Extensive and relevant research experience using rodent models of human disease
- Proficiency in a specialized therapeutic area such as fibrosis, virology, autoimmune disorders, immunology, and oncology
- Experience with oncology models
- Experience with in vitro / ex vivo assay development
- Hands-on knowledge of general laboratory techniques, including basic molecular or cellular biology techniques (e.g. RNA/DNA isolation, gel electrophoresis, PCR, RNASeq, bacterial culture and transformation, Western Blot, ELISA, mammalian cell culture, etc.)
- Working familiarity with cell based immunology techniques such as MSD/ELISA and FACS
- Understanding of preclinical drug development and regulatory process
- Prior experience handling small molecules/biologics for PK/PD studies
Responsibilities
- Assist in the design and execution of in vivo rodent studies across various therapeutic areas with duties including animal weighing, dose administration (e.g. subQ, IP, PO, IM, retro-orbital, IV), blood and tissue collection, necropsy, oncology and functional readouts.
- Perform in vivo imaging and analysis of data in cancer models
- Proficient with cell culture techniques using various immortalized cell lines to support oncology studies is desired
- General understanding of pharmacokinetics, pharmacodynamics, and drug metabolism
- Ability to follow strict instructions on formulation of test compounds for in vivo dosing
- Analyze in vivo data independently or under minimal guidance of senior scientists
- Contribute to generation of reports for in vivo experiments or other related study presentations with guidance of senior scientists
- Work collaboratively with cross-functional teams to support department’s goals and timelines
- Aid in lab equipment maintenance and general lab support
- Maintain a safe laboratory environment by following standard operating procedures (SOP) and established IACUC protocols
- Other related duties as assigned
Benefits
- We offer excellent salary and benefits.
- Aragen is an equal opportunity employer.
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
