Research Associate Scientist I - Kalish Lab

Children’s Hospital of Philadelphia • Philadelphia, PA

6h

About The Position

This role is an independent researcher that plans, coordinates and executes research projects.

Works with the principal, investigator. Participates in and assists in the planning and coordination of research projects. Is independent and responsible for a specific aspect of one or more research project. Assists in determining the direction of the project.
About the Laboratory
The Kalish Lab studies how genetic and epigenetic alterations lead to overgrowth syndromes. This work focuses largely on patients with Beckwith-Wiedemann syndrome (BWS) and understanding the transition from normal growth to overgrowth to tumor formation. BWS is the most common cancer predisposition and growth disorder that leads to cancer in children. Children with BWS can develop overgrowth of a number of different organs and in some cases develop tumors, most commonly hepatoblastoma (liver cancer) and/or Wilms tumor (kidney cancer). Some of the same genetic and epigenetic changes that cause BWS are also seen in other types of cancer; therefore studying BWS is a window into understanding the larger questions about growth and the transition to cancer.
The Kalish Lab focuses on improving clinical care for children with BWS through clinical and translational research. The lab oversees the BWS registry and biorepository and its work uses clinical data and samples to understand the transition between normal growth, overgrowth, and cancer. The lab's clinical research focuses on improving care for the clinical features of BWS and understanding the correlations between those manifestations. Through this work the lab continues to develop national management guidelines for BWS. Its translational research focuses on how the epigenetic and genetic changes lead to the features of BWS including overgrowth and cancer, with goals of understanding these mechanisms and developing therapeutics.

Requirements

• At least seven (7) years of directly relevant post grad scientific lab experience Required
• Expert knowledge and experience working with iPSC and organoids
• Expert knowledge in the use of a wide variety of lab techniques, research equipment and research related software
• Excellent verbal and written communications skills
• Excellent organizational skills
• Excellent critical thinking / problem-solving skills
• Excellent analytical skills
• Solid interpersonal skills
• Basic leadership skills
• Bachelor's Degree Required

Nice To Haves

• At least nine (9) years of directly relevant post grad scientific lab experience Preferred
• Successful completion of a Post Doc Fellowship Preferred
• Master's Degree Preferred
• Doctorate Preferred

Responsibilities

• Assists faculty in the conduct of research of significant value in the basic and/or translational science area
• Plans, conducts research projects within the federal, institutional regulations and policies
• Collaborates with researchers, external agencies and institutions to develop cooperative research initiatives
• Trains technical staff, students in lab procedures
• Reviews manuscripts for peer-reviewed journals
• Assists with the submission of grant applications, contracts and research projects funding
• Participates in free discussion, research progress, and overall morale
• Responsible for appropriate use of research funds
• May supervise students or other research staff as assigned

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level