Research Associate, Protein Biochemistry

Flagship Pioneering•Cambridge, MA

1d•$65,000 - $93,500

About The Position

What if… you could pioneer a new approach to designing life's most essential molecules? FL116, backed by Flagship Pioneering, is an early-stage biotechnology company transforming the way biomolecules are synthesized. Our innovative platform has the potential to transform the way these critical research, diagnostic, and therapeutic tools are manufactured. We are seeking passionate problem solvers ready to make a profound impact on biotechnology and therapeutic innovation. Position Summary: We are seeking a motivated and creative Research Associate to join our team focused on protein expression, purification, and innovation . The successful candidate will contribute to the production, purification, and functional characterization of recombinant proteins supporting our research and development efforts. This is an exciting opportunity to join a growing interdisciplinary team and help establish core protein capabilities for a breakthrough synthesis platform.

Requirements

Bachelor’s degree in Biochemistry, Molecular Biology, or related field with 2+ years of relevant laboratory experience
Hands-on experience with molecular biology and protein techniques (academic or industry settings)

Nice To Haves

Experience with cell-free and cell-based protein expression
Strong analytical and organizational skills with attention to detail
Ability to manage multiple tasks, work independently, and thrive in a collaborative team environment
Familiarity with lab information management systems (LIMS), electronic lab notebooks (ELNs), or related data-management tools
Enthusiasm for learning and optimizing new techniques in a fast-paced, innovative environment

Responsibilities

Express recombinant proteins in cell-free, bacterial, and yeast systems, in bulk and at high throughput.
Purify proteins using chromatographic techniques such as affinity (Ni-NTA, GST), ion exchange, and size exclusion chromatography
Analyze protein samples using SDS-PAGE, Western blotting, BCA assays, and other biochemical methods
Develop and optimize activity and characterization assays for purified proteins, both in bulk and at high throughput
Maintain accurate and detailed lab records, including batch records and experiment documentation
Assist in troubleshooting expression or purification challenges and optimizing protocols
Prepare buffers and reagents, maintain reagent stocks, and ensure high laboratory standards
Collaborate closely with team members to achieve project goals and timelines
Comply with lab safety protocols and best practices in protein handling and biohazard management