Research Associate II/Senior Research Associate, Discovery

CAMP4 Therapeutics • Cambridge, MA

3d • $85,000 - $110,000

About The Position

CAMP4 is leveraging a proprietary drug discovery platform to discover antisense oligonucleotides (ASOs) targeting regulatory RNAs to treat a broad range of central nervous system diseases. We are seeking a passionate Research Associate II/ Senior Research Associate to join the Discovery team responsible for driving a pipeline of programs. You will work closely with the Platform, Chemistry, Data Science, and Preclinical teams to generate data supporting the advancement of pipeline projects. A key responsibility for this role will be to support our efforts using patient iPSC-derived neurons to validate targets and screen candidate ASOs. A successful candidate will apply their experience in human iPSC maintenance and neuronal differentiation along with assay development to characterize the effects of candidate ASOs on target engagement and phenotypic rescue. This is an exciting opportunity for a self-motivated, team-oriented, and collaborative individual with outstanding organizational and communication skills. Title commensurate with experience.

Requirements

• BS or MS degree in neuroscience, cell biology, molecular biology or a similar discipline with 2+ years of industry or academic research experience.
• Demonstrated expertise in cell culture experimental skills, including experience with human iPSC culture and differentiation.
• Experience with molecular biology techniques including RNA isolation, QPCR, and western blot.
• Team-oriented, highly motivated with a strong work ethic, ability to work productively in a fast-paced collaborative environment that requires a high level of organization and communication.
• Demonstrated attention to detail and time management skills.

Nice To Haves

• Experience with immunofluorescence staining, microscopy, and ELISAs is preferred.

Responsibilities

• Help develop robust differentiation, and scalable platforms to generate various types of functional neurons and glial cells from human iPSCs.
• Assess effects of ASOs on RNA/protein in iPSC-derived neurons.
• Establish biochemical (e.g., ELISA) and/or cellular functional assays (e.g., multielectrode array) for target validation and to assess ASO activity.
• Support in vivo pharmacology and efficacy studies by analyzing mouse tissue samples for RNA and protein (no direct animal work).
• Provide input into experimental design, data analysis, and communication of results to the broader scientific teams.
• Maintain detailed records of experimental design and results in electronic lab notebook.
• Support daily laboratory operation and maintenance including preparing and ordering necessary reagents and supplies, equipment maintenance, and other periodic lab activities.

Benefits

• At CAMP4 Therapeutics, we offer a competitive and thoughtfully designed total rewards program.
• In addition to base salary, employees are eligible to receive an annual bonus and equity incentive opportunities.
• Our benefits include medical, dental, and vision insurance; life and disability coverage; paid parental leave; a 401(k) plan with company contribution; Employee Stock Purchase Program, Trek Time (flexible time off); tuition assistance; and additional perks that support your well-being and professional growth.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level