About The Position

Join the forefront of groundbreaking research at City of Hope where our mission is to transform the future of cancer care through precision medicine and innovative immuno-oncology. We are seeking a highly motivated and hands-on Research Associate II to support laboratory-based research on colorectal cancer immunotherapy and tumor microenvironment biology. This position is ideal for a candidate eager to gain advanced experience in spatial and single-cell technologies, clinical translational research, and biomarker discovery. The successful candidate will work closely with Dr. Marwan Fakih and Dr. Jian Ye, contributing directly to ongoing clinical-correlative studies and mechanistic projects using cutting-edge techniques. You will be part of a translational research team tackling immunotherapy resistance in colorectal cancer, using state-of-the-art spatial and molecular platforms. This position provides an exceptional opportunity to develop hands-on skills in both clinical sample handling and cutting-edge research technologies, with publication opportunities.

Requirements

  • Bachelor's degree in Biology, Molecular Biology, Immunology ore related field. Master's degree preferred.
  • Two years related research/ laboratory experience with a Bachelor's degree or one year related research/ laboratory experience with a Master's degree.

Nice To Haves

  • Prior experience with immunohistochemistry, flow cytometry, or molecular biology techniques is strongly preferred.
  • Experience with spatial transcriptomics, multiplex imaging, or single-cell technologies is a plus but not required.
  • Strong motivation to learn and contribute to both clinical and basic cancer research.
  • Ideal for candidates interested in pursuing future graduate, medical, or academic research careers.

Responsibilities

  • Perform wet-lab and technical experimental work related to translational immuno-oncology studies in colorectal cancer.
  • Process and manage clinical biospecimens (tumor tissues, blood, and FFPE samples) for downstream molecular and spatial analyses.
  • Conduct advanced spatial biology and immunology assays.
  • Maintain organized sample inventory, records, and reagent tracking.
  • Assist with basic data analysis, figure preparation, and presentation of results.
  • Collaborate with clinicians and scientists to integrate molecular and imaging data for mechanistic and biomarker discovery studies.
  • Contribute to the preparation of research reports, manuscripts, and grant applications.
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