RESEARCH ASSISTANT Sr.- Immuno-Oncology

The Scripps Research Institute•San Diego, CA

65d•Onsite

About The Position

Calibr-Skaggs is seeking a talented Research Assistant in the area of Immuno-Oncology. This position will work as part of a small team of interdisciplinary scientists to translate novel cell and protein therapies for the treatment of cancer into first in human clinical trials. Specifically, projects will be focused on the development of a gene therapy referred to as chimeric antigen receptor T (CAR-T cell) and in the development of immunotherapies known as CD3 T cell recruiting bispecific antibody platforms. Both platform technologies have the potential to have curative responses in the clinic for cancer patients. While working within the scope of these projects, this position will also have the unique opportunity to be exposed to a wide range of other projects at Calibr-Skaggs covering infectious and neglected tropical diseases, metabolic disorders, autoimmunity, and others. Calibr-Skaggs' open lab space design and collaborative environment encourages the seamless flow of ideas within and between research groups. This position will receive hands-on training in translational research and is expected to bring the basic scientific proficiencies listed below at the start. This position offers significant growth opportunity through promotion structures designed to retain exceptional talent within the Calibr-Skaggs family.

Requirements

Requires a Bachelor's degree in a relevant scientific discipline or an equivalent combination of education, training and/or experience from which comparable knowledge, skill and abilities have been attained.
Requires a minimum of 10 years experience. Candidates possessing a Master's degree, a minimum of 7+ years experience required.
Excellent ability to perform hands on experiments, attention to detail, research, design, and organize project designs and maintain detailed documentation.
Highly motivated, creative, and devoted to project goals.
Must be able to collaborate proficiently and communicate effectively with colleagues and management teams.
Must be able to contribute in a meaningful way to scientific discourse.
A strong background in cell culture is essential. The candidate must have experience working with primary human immune cells and culturing cell lines including, but not limited to, common tumor cell lines used in immuno-oncology research.
Hands-on experience with in vitro assays commonly used in immuno-oncology is critical. The candidate must have experience assessing the activity of immune cells using in vitro assays such as cytotoxicity, proliferation, and activation assays.
Experience with multi-color flow cytometry is required. The candidate should have experience with multi-color flow cytometry and flow data analysis.

Nice To Haves

Experience and knowledge of the immune system is a plus. The candidate must show a fundamental understanding of the immune system. Experience in T cell biology, tumor immunology, as well as other immune components is preferred.
Experience preparing reagents for in vivo assays is desired, as well as experience in processing (blood, liver, spleen, tumor), and analysis of samples from in vivo experiments.
Experience with molecular biology techniques is preferred. Experiments include but are not limited to molecular cloning, DNA preparation, protein expression/purification, immunoprecipitation, Western blots, ELISAs, etc.
Experience with cell transfection and transduction systems is a plus. The candidate will be required to generate high-quality lentivirus for the transduction of both primary immune cells and established cell lines.
Experience using programs such as GraphPad Prism, FlowJo, and Office software is beneficial but not required.

Responsibilities

Work under minimal supervision. Independently conducts a wide variety of standard laboratory techniques/procedures while using judgement when necessary to adapt standard methods and techniques. Receive instructions on specific assignment objectives, complex features, and possible solutions.
Provide interpretation and analyses of results. Troubleshoot and modify procedures.
May assist in designing experiments to complete a segment of overall research plan. May provide routine equipment maintenance. May provide guidance/training to department.

Benefits

Eligibility for retirement plans with employer contribution.
Full suite of Health and Welfare plans including three medical plan options (including an HSA available option), dental, vision, life insurance, disability, EAP and more.
Access to Flexible Spending Accounts (Medical/Dependent Care).
Competitive vacation and sick leave policies.
Free, on-site Counseling Center which provides confidential counseling services to benefits-eligible employees and their family members.
Free, on-site parking.

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