The Mo lab seeks to understand the mechanisms of neurodevelopmental disorders using molecular biology, genomic, biochemical, and computational approaches. We are broadly interested in two areas: 1) the impacts of somatic mutations in brain development and disease; and 2) the mechanisms of specific genetic causes of autism and intellectual disability. Ongoing projects include using induced pluripotent stem cells and neural progenitor cells to model somatic mosaicism, characterizing the distribution of somatic mosaicism in neurotypical and autism brains, and using single cell multiomic techniques to study specific subtypes of autism. We use a variety of techniques and materials such as next generation sequencing, cell culture models, postmortem human brain tissue, and computational tools.