The Ushiki Lab investigates the molecular mechanisms of transcriptional regulation and how noncoding genetic variation alters gene regulation in human disease. Our work integrates functional genomics, human genetics, and in vivo experimental systems to understand enhancer function across regulatory and phenotypic scales. We develop and apply both experimental and computational approaches, including in vivo Massively Parallel Reporter Assays (MPRAs), to define the sequence basis and functional consequences of enhancer activity and to expand MPRA-based approaches to other aspects of transcriptional regulation. Ongoing work in the lab is supported by an NHGRI K99/R00 award and the Preeclampsia Foundation’s Peter Joseph Pappas Research Grant. Assists with various aspects of the research process in a laboratory setting under the direction of the PI and/or experienced laboratory personnel in order to gain experience to further future career opportunities. Guided activities may include literature review and initial research to identify experimental opportunities, experimental design, execution of experiments and troubleshooting, collection and analysis of data, and/or communication/presentation of results. This role is well-suited for those interested in a gap year(s) where they will be spending time in a research lab acquiring new skills under the direction of the PI and/or experienced laboratory personnel.
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Job Type
Full-time
Career Level
Entry Level
Number of Employees
1,001-5,000 employees