Purification Development Scientist 1

Genentech • Philadelphia, PA

1d

About The Position

The Opportunity
At Spark Therapeutics, the downstream process development (DSPD) team is seeking a highly motivated Scientist 1 with relevant industry experience to join
the team. The successful candidate will participate in multiple downstream
process development programs in Roche’s innovative pipeline.
What You'll Do
- Execute lab experiments according to predefined experimental design and protocols.
- Support the maintenance of essential equipment and critical raw materials to ensure smooth laboratory operations.
- Maintain comprehensive and accurate documentation with a high level of detail. Close out experiments in a timely manner while preparing and submitting well-written development reports.
- Collaborate with team members to ensure the DSP laboratories are maintained in a professional and organized working environment.
- Contribute to the troubleshooting, optimization, and scale-up of downstream processes to meet project objectives.
Who You Are
Master/Bachelor in biochemistry, chemistry, chemical engineering, bioengineering, or related area with 0-4 years of relevant industry experience.
Knowledge of downstream process development of the biologics, such as viral vectors, monoclonal antibodies, vaccines, and therapeutic recombinant proteins in the biopharma industry
Hands-on experience with operating chromatography and filtration systems
Working knowledge and skills for viral vector or vaccine purification is a plus.
Working knowledge and skills for lipid nanoparticle (LNP) production is a plus
Working knowledge of analytical techniques for in process testing or product characterization is a plus
In-depth understanding in at least one of the following aspects is a plus: Chromatography, Tangential Flow Filtration (TFF) and T-mix operations.

Requirements

• Master/Bachelor in biochemistry, chemistry, chemical engineering, bioengineering, or related area with 0-4 years of relevant industry experience.
• Knowledge of downstream process development of the biologics, such as viral vectors, monoclonal antibodies, vaccines, and therapeutic recombinant proteins in the biopharma industry
• Hands-on experience with operating chromatography and filtration systems
• Strong organizational skills and detailed documentation abilities are required.
• Perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies.
• Excellent writing and verbal communication skills are required.
• Teamwork is a must.
• Must be comfortable in the fast-paced, multi-tasking biotech environment
• Must be able to lift 25 pounds
• Must be flexible with work schedule and available to work extended hours if needed
• Must be able to wear all Personal Protective Equipment as required
• Must be able to stand for long periods

Nice To Haves

• Working knowledge and skills for viral vector or vaccine purification is a plus.
• Working knowledge and skills for lipid nanoparticle (LNP) production is a plus
• Working knowledge of analytical techniques for in process testing or product characterization is a plus
• In-depth understanding in at least one of the following aspects is a plus: Chromatography, Tangential Flow Filtration (TFF) and T-mix operations.

Responsibilities

• Execute lab experiments according to predefined experimental design and protocols.
• Support the maintenance of essential equipment and critical raw materials to ensure smooth laboratory operations.
• Maintain comprehensive and accurate documentation with a high level of detail. Close out experiments in a timely manner while preparing and submitting well-written development reports.
• Collaborate with team members to ensure the DSP laboratories are maintained in a professional and organized working environment.
• Contribute to the troubleshooting, optimization, and scale-up of downstream processes to meet project objectives.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level