Protein Engineering Scientist, Gene Therapy Engineering

Neurocrine Biosciences • San Diego, CA

1d

About The Position

Perform protein engineering to advance the development of novel gene therapies. Will design and perform protein variants and conduct in vitro screening for improved tropism and other critical attributes. Working with our Collaboration Partners and internal colleagues in Research, CMC, and Business Development, the individual will participate in work on new and existing programs. _ Your Contributions (include, but are not limited to): The primary role is to design, produce, and screen novel proteins modification of differing biological modalities to advance gene therapy programs Apply rational structural and computational approaches in protein engineering for improved attributes aligning with program goals Design and execute molecular biology and in vitro experiments in support of gene therapy programs Independently recommend alternatives, research new methods and techniques, and proactively seek out senior personnel to discuss potential solutions Prepare data summaries and present results to peers and colleagues at Neurocrine Provides training and/or supervision to junior staff, as needed Other tasks as assigned The primary role is to design, produce, and screen novel proteins modification of differing biological modalities to advance gene therapy programs Apply rational structural and computational approaches in protein engineering for improved attributes aligning with program goals Design and execute molecular biology and in vitro experiments in support of gene therapy programs

Requirements

• BS/BA degree in biology and 2+ years of relevant experience OR MS/MA degree in biology and some relevant industry experience preferred OR PhD or equivalent and some relevant experience
• Knowledge of protein engineering, including structural analysis and application of computational approaches
• Expertise in molecular biology, including techniques such as biology techniques such as PCR, digital PCR, gel electrophoresis, western blot/ELISA, plasmid design, cloning, and sequencing
• Experience in cell culture work, especially AAV or antibody production, including plasmid transfection, cell material processing, and purification
• Programming proficiency is strongly preferred, especially in Python
• Familiarity with protein engineering tools, such as PyMol, MolStar, and AlphaFold; experience with ML applications such as DiffDock, BoltzGen, etc. are a plus
• Backgrounds in neuroscience and/or sequencing technologies are a plus
• Excellent critical analysis skills and ability to assess data and research findings outside of Neurocrine for application to new scientific projects
• Advanced knowledge and demonstrated ability to work with a variety of laboratory equipment/tools
• Ability to work as part of teams
• Excellent computer skills
• Excellent communication skills
• Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency
• Knowledge of protein engineering, including structural analysis and application of computational approaches
• Expertise in molecular biology, including techniques such as biology techniques such as PCR, digital PCR, gel electrophoresis, western blot/ELISA, plasmid design, cloning, and sequencing
• Experience in cell culture work, especially AAV or antibody production, including plasmid transfection, cell material processing, and purification
• Programming proficiency is strongly preferred, especially in Python
• Familiarity with protein engineering tools, such as PyMol, MolStar, and AlphaFold; experience with ML applications such as DiffDock, BoltzGen, etc. are a plus
• Backgrounds in neuroscience and/or sequencing technologies are a plus
• Excellent critical analysis skills and ability to assess data and research findings outside of Neurocrine for application to new scientific projects
• Advanced knowledge and demonstrated ability to work with a variety of laboratory equipment/tools
• Ability to work as part of teams

Nice To Haves

• BS/BA degree in biology and 2+ years of relevant experience OR MS/MA degree in biology and some relevant industry experience preferred OR PhD or equivalent and some relevant experience
• Familiarity with protein engineering tools, such as PyMol, MolStar, and AlphaFold; experience with ML applications such as DiffDock, BoltzGen, etc. are a plus
• Backgrounds in neuroscience and/or sequencing technologies are a plus
• Familiarity with protein engineering tools, such as PyMol, MolStar, and AlphaFold; experience with ML applications such as DiffDock, BoltzGen, etc. are a plus
• Backgrounds in neuroscience and/or sequencing technologies are a plus

Responsibilities

• The primary role is to design, produce, and screen novel proteins modification of differing biological modalities to advance gene therapy programs
• Apply rational structural and computational approaches in protein engineering for improved attributes aligning with program goals
• Design and execute molecular biology and in vitro experiments in support of gene therapy programs
• Independently recommend alternatives, research new methods and techniques, and proactively seek out senior personnel to discuss potential solutions
• Prepare data summaries and present results to peers and colleagues at Neurocrine
• Provides training and/or supervision to junior staff, as needed
• Other tasks as assigned
• The primary role is to design, produce, and screen novel proteins modification of differing biological modalities to advance gene therapy programs
• Apply rational structural and computational approaches in protein engineering for improved attributes aligning with program goals
• Design and execute molecular biology and in vitro experiments in support of gene therapy programs

Benefits

• Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 1,001-5,000 employees