Process Development Engineer I - Late Stage Purification (PMPD)

Regeneron Pharmaceuticals • Tarrytown, NY

32d • Onsite

About The Position

Regeneron's Late-Stage Purification Development team within PMPD (Preclinical Manufacturing and Process Development) is seeking a full-time Process Development Engineer I. In this role, you will be responsible for the development and transfer of the harvest, affinity chromatography, and viral inactivation unit operations for recombinant proteins using Quality by Design principles. A Typical Day in the Role Might Look Like: Designs and executes experiments at both bench and pilot-scale Analyzes data, draws conclusions from results, and proposes next steps Documents results in laboratory notebook and reports Communicates findings to functional area and department leadership Acts as purification development subject matter expert during manufacturing process transfer to ensure successful completion of GMP batches Works cross-functionally with the process development team to enable a robust, cohesive manufacturing process Supports technology development and improvement activities potentially including but not limited to: automation of pilot-scale unit operations, improving bench-scale process models, developing workflows for compilation and analysis of historical data, investigating new raw materials, equipment, and/or techniques to advance the harvest, affinity chromatography, and viral inactivation unit operations Trains peers and directly or indirectly manages, mentors, and assists co-op students and interns in conducting experiments, analyzing data, and documenting results. Contributes to lab equipment maintenance and general lab safety to help create a safe, effective, and efficient working environment This Role Might Be For You If You: Have a solid understanding and practical experience in purifying monoclonal antibodies or other biopharmaceuticals Enjoy spending ~50-70% of time performing lab work at both bench and pilot-scale Have experience with process automation, specifically hardware, control logic, and/or HMI development Thrive in a team-based, collaborative environment Are well organized and able to manage multiple projects efficiently Are an effective communicator within all levels of an organization Are scientifically curious, creative, and have a problem-solver mentality

Requirements

• Bachelor's and/ or Master's degree in either Chemical Engineering, Biochemical Engineering, Biochemistry, or a related field with 3-5/0-2 years of recombinant protein purification experience, including some but not limited to depth filtration, disc stack centrifugation, column chromatography, virus retentive filtration, ultrafiltration/diafiltration, buffer preparation.

Nice To Haves

• A strong fundamental understanding of various protein purification techniques and experience with Akta chromatography systems, HPLC, UPLC, Empower, Unicorn, JMP, LIMS, Python, Ignition, and PI Historian is a plus.

Responsibilities

• Designs and executes experiments at both bench and pilot-scale
• Analyzes data, draws conclusions from results, and proposes next steps
• Documents results in laboratory notebook and reports
• Communicates findings to functional area and department leadership
• Acts as purification development subject matter expert during manufacturing process transfer to ensure successful completion of GMP batches
• Works cross-functionally with the process development team to enable a robust, cohesive manufacturing process
• Supports technology development and improvement activities potentially including but not limited to: automation of pilot-scale unit operations, improving bench-scale process models, developing workflows for compilation and analysis of historical data, investigating new raw materials, equipment, and/or techniques to advance the harvest, affinity chromatography, and viral inactivation unit operations
• Trains peers and directly or indirectly manages, mentors, and assists co-op students and interns in conducting experiments, analyzing data, and documenting results.
• Contributes to lab equipment maintenance and general lab safety to help create a safe, effective, and efficient working environment

Benefits

• comprehensive benefits, which vary by location
• health and wellness programs (including medical, dental, vision, life, and disability insurance)
• fitness centers
• 401(k) company match
• family support benefits
• equity awards
• annual bonuses
• paid time off
• paid leaves (e.g., military and parental leave)

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Industry: Chemical Manufacturing
• Number of Employees: 5,001-10,000 employees