Process Development Associate - Late Stage Purification Development (PMPD)

Regeneron Pharmaceuticals • Tarrytown, NY

51d • Onsite

About The Position

Regeneron's Late-Stage Purification Development team within PMPD (Preclinical Manufacturing and Process Development) is seeking a full-time Process Development Associate. In this role, you will be responsible for the development and transfer of the harvest, affinity chromatography, and viral inactivation unit operations for recombinant proteins using Quality by Design principles.

A Typical Day in the Role Might Look Like:

Designs and executes experiments at both bench and pilot-scale
Analyzes data, draws conclusions from results, and proposes next steps
Documents results in laboratory notebook and reports
Communicates findings to functional area and department leadership
Acts as purification development subject matter expert during manufacturing process transfer to ensure successful completion of GMP batches
Works cross-functionally with the process development team to enable a robust, cohesive manufacturing process
Supports technology development and improvement activities potentially including but not limited to: automation of pilot-scale unit operations, improving bench-scale process models, developing workflows for compilation and analysis of historical data, investigating new raw materials, equipment, and/or techniques to advance the harvest, affinity chromatography, and viral inactivation unit operations
Trains peers and directly or indirectly manages, mentors, and assists co-op students and interns in conducting experiments, analyzing data, and documenting results.
Contributes to lab equipment maintenance and general lab safety to help create a safe, effective, and efficient working environment

Requirements

• Have a solid understanding and practical experience in purifying monoclonal antibodies or other biopharmaceuticals
• Enjoy spending ~50-70% of time performing lab work at both bench and pilot-scale
• Are well organized and able to manage multiple projects efficiently
• Are an effective communicator within all levels of an organization
• Are scientifically curious, creative, and have a problem-solver mentality
• This role requires a Bachelor's degree in either Chemical Engineering, Biochemical Engineering, Biochemistry, or a related field with 0 - 2 years of recombinant protein purification experience, including some but not limited to depth filtration, disc stack centrifugation, column chromatography, virus retentive filtration, ultrafiltration/diafiltration, buffer preparation

Nice To Haves

• Have experience with process automation, specifically hardware, control logic, and/or HMI development
• A strong fundamental understanding of various protein purification techniques and experience with Akta chromatography systems, HPLC, UPLC, Empower, Unicorn, JMP, LIMS, Python, Ignition, and PI Historian is a plus.

Responsibilities

• Designs and executes experiments at both bench and pilot-scale
• Analyzes data, draws conclusions from results, and proposes next steps
• Documents results in laboratory notebook and reports
• Communicates findings to functional area and department leadership
• Acts as purification development subject matter expert during manufacturing process transfer to ensure successful completion of GMP batches
• Works cross-functionally with the process development team to enable a robust, cohesive manufacturing process
• Supports technology development and improvement activities potentially including but not limited to: automation of pilot-scale unit operations, improving bench-scale process models, developing workflows for compilation and analysis of historical data, investigating new raw materials, equipment, and/or techniques to advance the harvest, affinity chromatography, and viral inactivation unit operations
• Trains peers and directly or indirectly manages, mentors, and assists co-op students and interns in conducting experiments, analyzing data, and documenting results.
• Contributes to lab equipment maintenance and general lab safety to help create a safe, effective, and efficient working environment

Benefits

• We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels!
• For additional information about Regeneron benefits in the US, please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/.
• For other countries' specific benefits, please speak to your recruiter.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Industry: Chemical Manufacturing
• Number of Employees: 5,001-10,000 employees