Process Chemistry Senior Principal Scientist

Vertex Pharmaceuticals • Boston, MA

83d • $153,600 - $230,400

About The Position

The successful candidate will possess a deep knowledge of process chemistry skills for the development of synthetic routes, with early and late-phase development experience and delivering drug substance under tight timelines. They will have a strong interest in laboratory work and will be key to driving the development of safe and scalable chemistry. They will spearhead the advancement of Vertex's portfolio through personal laboratory effort as well as overseeing internal and external resources. They will leverage additional Vertex resources (high-throughput experimentation, engineering and material sciences, process safety, analytical, etc.) to assist in identifying and optimizing reaction conditions for key transformations. The successful candidate will represent process chemistry in cross-functional teams requiring good communication skills. The successful candidate will have accountability for creating and developing a synthetic route to deliver active pharmaceutical ingredients (APIs) within a specification range fit for the phase of development and delivering the technology and materials to enable candidate progression through development. The Sr. Principal Scientist Process Chemistry will lead/participate in cross-functional technical teams within their field of expertise. They will also be responsible for mentoring internal process chemistry scientists and promote the department through publications in peer reviewed journals and participation in external conferences.

Requirements

• Bachelor's degree and 11+ years of experience or a Master's degree and 9+ years of experience or a PhD and 6-8+ years of experience in the pharmaceutical industry
• A track record of successfully achieving goals and solving problems in the pharma environment
• Ability to communicate difficult concepts, ideas, and solutions to project teams and leadership
• Knowledge and understanding regulatory factors and maintaining expert knowledge in chemistry

Responsibilities

• Demonstrates advanced intellectual and technical leadership
• Familiar with early and late phase pharmaceutical development and regulatory expectations
• Work with Pharm Sci team to develop project strategy, timelines, and leverages technical skills as a Process Chemistry expert within Vertex
• Individual lab work focused on developing safe, scalable processes
• Seek to employ state-of-the art technologies, including flow chemistry, photochemistry, electrochemistry, computational and predictive tools
• Contribute directly to technology transfer to internal sites or external vendors
• Proactively identifies and oversees vendors to gain access to technologies as needed to deliver pipeline
• Leverage cross-functional knowledge to guide pharmaceutical sciences teams on potential impact of decisions
• Assess data integrity to provide expert interpretation and recommendations to project teams and leadership
• Present synthetic and experimental plans clearly and persuasively to all parts of the organization
• Recognized as a technical leader by the group and may mentor junior staff
• Authors publication, patent, and regulatory submissions

Benefits

• Medical, dental and vision benefits
• Generous paid time off including a week-long company shutdown in the Summer and the Winter
• Educational assistance programs including student loan repayment
• Generous commuting subsidy
• Matching charitable donations
• 401(k) and annual bonus and equity awards

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Chemical Manufacturing
• Education Level: Ph.D. or professional degree