Principal Statistical Programmer

Rapport Therapeutics•Boston, MA

8h•$180,000 - $200,000•Hybrid

About The Position

When our people share why they joined Rapport and love it here, it comes down to three things: the science, the mission, and the team. At Rapport, we’re driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we’re doing this with extraordinary science and awesome people (affectionately called Rapptors). Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies. We are excited about the potential of our lead program, RAP-219. Our first indication targets focal epilepsy with additional clinical trials for neuropathic pain and bipolar disorder. The strength of Rapport comes from our Rapptors – who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you’re as excited about this opportunity as we are! Your impact: The Principal Statistical Programmer or Associate Director of Statistical Programming is responsible for providing clinical trial studies stat programming leadership, strategic guidance and technical support of high quality stats data output within Rapport’s clinical development programs. This role reports directly to the Head of Statistical Programming in the Biometric group’s

Requirements

Master’s or Bachelor’s degree in Computer Science, Statistics, Mathematics, Life Sciences, or a related field.
8-10+ years of experience in statistical programming within the biotech/pharmaceutical industry
Title and level commensurate with experience
Proven ability to build, lead, and develop high-performing programming teams, with a demonstrated track record of mentoring talent, fostering a collaborative culture, and aligning team objectives with broader organizational goals.
Expert-level proficiency in SAS (Base, Macro, STAT, GRAPH) and experience with CDISC standards (SDTM, ADaM).
Proven track record of supporting successful regulatory submissions (e.g., NDA, BLA, MAA).
In-depth knowledge of clinical trial processes, GCP, regulatory requirements (FDA, EMA), and ICH guidelines.
Strong project management skills and ability to manage multiple priorities in a fast-paced environment.
Experience managing and developing high-performing teams, both internal and external (CRO/vendor).
Excellent interpersonal, communication, and leadership skills.

Nice To Haves

Familiarity with R, Python, or other programming languages is a plus.
Experience in Neurology or CSN highly desirable

Responsibilities

Lead Statistical Programming activities across all stages of clinical development (Phase I-IV), from protocol development design to clinical study report (CSR), health agency submission and post-marketing activities.
Review and understand study documents, including the Protocol, electronic case Report Forms (eCRFs), Statistical Analysis Plans (SAPs) and CSR.
Lead clinical trial study project design, development, validation, and documentation of SAS programs for data analysis, TFL (tables, listings, figures) generation, and CDISC deliverables (SDTM, ADaM).
Ensure compliance with industry standards (CDISC, ICH, FDA/EMA guidance) and company SOPs.
Provide programming oversight for regulatory submissions (e.g., NDA/BLA/MAA), including eCTD packages, define.xml, and reviewer guides (cSDRG and ADRG).
Lead the development and implementation of programming standards, automation tools, and quality control processes.
Serve as a subject matter expert for programming strategy, data standards, and regulatory expectations.
Collaborate with Biostatistics leadership to ensure integration of statistical and programming workflows.
Hire, manage and coach different level stat programmers to establish a strong and motivated statistical programming team.
Manage outsourcing strategy and oversee deliverables from CROs and external vendors.
Contribute to cross-functional initiatives to improve data quality, efficiency, and innovation in clinical development.

Benefits

Every role has meaning. We’re determined to discover a better way for patients, and you’ll feel the passion from the start.
We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities.
Your perspective matters. Stick your neck out, share your ideas – we work as a team.
We have FUN. We hire smart, dedicated, down-to-earth people that you’ll enjoy spending time with.
Leadership that CARES – about you, your growth + development.
We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston – we make the most of our time together.
Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more!
You get to be YOU! Show up as you are and make every day count.

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