Principal/ Senior Scientist – T Cell Engager & Multispecific Protein Engineering

PharmaEssentia U. • Bedford, MA

41d

About The Position

Principal/ Senior Scientist – T Cell Engager & Multispecific Protein Engineering Position Overview PharmaEssentia is a global biopharmaceutical company dedicated to developing innovative therapies for patients with unmet medical needs in oncology, hematology, and immunology. With strong capabilities in disease biology, biologics and translational science, we are expanding our research organization to drive the next generation of therapeutic breakthroughs. The PharmaEssentia Innovation Research Center (PIRC) is seeking a highly motivated and collaborative Principal/ Senior Scientist to join our Biologics Platform team. This role will play a key role in the discovery, design, and optimization of T cell engager and multispecific protein therapeutics, advancing programs from early discovery through preclinical development. The successful candidate will combine deep expertise in protein engineering, antibody and multispecific formats, and immuno-oncology biology with strong scientific leadership and hands-on execution. This position provides the opportunity to help shape next-generation biologics platforms and advance first-in-class or best-in-class therapeutic programs.

Requirements

• PhD in Immunology, Protein Engineering, Biochemistry, Molecular Biology, or a related field, with 7+ years of relevant industry experience in biologics or protein therapeutics discovery (4+ years for Senior Scientist level).
• Demonstrated expertise in protein and antibody engineering, including multispecific or immune-redirecting modalities (e.g., T cell engagers).
• Strong understanding of T cell biology, immune synapse mechanisms, and CD3-based targeting strategies.
• Experience leading or significantly contributing to biologics discovery programs from early discovery through lead optimization.
• Track record of scientific contributions, including peer-reviewed publications, patents, or advancement of molecules into preclinical development.

Nice To Haves

• Experience and knowledge in AI-driven protein foundation model for protein engineering is a plus.
• Demonstrated experience providing project leadership in biologics discovery, including coordination of cross-functional teams and advancement of candidates toward IND-enabling studies.
• Experience in T cell receptor (TCR) biology and engineering, including affinity tuning, specificity optimization, and/or TCR-based therapeutic modalities.
• Experience with yeast display or other directed evolution platforms for high-throughput antibody or TCR screening.

Responsibilities

• Design, engineer, and optimize T cell engager modalities , including bispecific and multispecific antibodies and novel protein scaffolds, to improve potency, selectivity, safety profile, and developability.
• Develop and execute protein engineering strategies to optimize affinity, stability, expression, pharmacokinetics/pharmacodynamics (PK/PD), and manufacturability.
• Collaborate with internal teams and external partners/CROs on protein production, biophysical characterization, and cell-based functional assays .
• Partner with biology and translational teams to evaluate T cell activation, immune synapse formation, cytokine release risk, and safety mitigation strategies
• Provide scientific and technical leadership for biologics discovery programs , driving molecule design, screening strategies, and candidate selection.
• Foster a culture of scientific rigor, transparency, collaboration, accountability, and inclusion within the research team.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree