Principal/Senior Principal Scientist, Immunoassays

Janux Therapeutics • San Diego, CA

371d • $145,000 - $200,000

About The Position

As a member of the pharmacology group, we seek a scientifically curious and motivated Principal or Senior Principal Scientist with an ability to work in a fast-paced environment. The incumbent will develop and execute the Immunoassay method development to support nonclinical and clinical sample analysis, as well as assay transfer to CRO and study monitoring. This position is hands-on and requires the effective study execution, communication, and documentation of results that enable the advancement of prototype method to fully validated assays. Strong candidates will be creative, collaborative, and passionate about drug discovery and assay development. Expertise in immunoassays (e.g. ADA and NAb assays) and immunology are required. As a strategic team member, they directly support decision-making for pipeline programs as they progress from early research through an IND and into the clinic. This position will report directly to the Director of In-Vivo Pharmacology.

Requirements

• Ph.D. in Biology, Immunology, Cell Biology, Biotechnology, or a related discipline + at least 5 years of assay development experience, MS + 10 years of assay development experience, or BS + 12 years of assay development experience in a biotechnology setting is required.
• Extensive experience in ADA and NAb assay development and assay validation.
• Large molecule/Biologic modality experience is a must for this position.
• Strong understanding and prior experience working in GxP environment is preferred.
• Experience with Ligand bind based PK assay development is a plus.
• Hands-on expertise with standard lab techniques such as ELISA, MSD and cell-based assays are required.
• Experience working with external CROs (due diligence, proposals, oversight, project management, data analyses, and reporting) is highly desirable.
• Competence in data analysis tools (Excel, GraphPad).
• Strong analytical and critical thinking skills with the ability to work in a fast-paced environment.
• Excellent written and oral communication skills.

Nice To Haves

• Experience with Ligand bind based PK assay development is a plus.
• Experience working with external CROs (due diligence, proposals, oversight, project management, data analyses, and reporting) is highly desirable.

Responsibilities

• Identify, develop and execute immunoassays to support both preclinical and clinical studies.
• Independently design and execute ADA and NAb assay from assay development, qualification, sample analysis, data analysis, report and SOP drafting.
• Be responsible for the assay transfer to CROs, and manage associated CRO activities for immunoassays.
• Provide input on technical inquiries and lead troubleshooting of immunoassays.
• Analyze and present experimental data using Prism, Excel, MS Office or similar software, and present findings to cross-functional groups.
• Train and support junior team members to manage and execute complex experimental testing.
• Produce detailed documentation of experiments within a lab notebook and electronically.
• Schedule and prioritize workload effectively within a fast-paced environment.
• Other duties as assigned.

Benefits

• 401K
• Medical insurance
• Dental insurance
• Vision insurance
• Supplemental disability insurance plans
• Flexible schedule
• Life insurance
• Flexible vacation
• Sick time
• Incentive stock option plan
• Relocation assistance

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Professional, Scientific, and Technical Services
• Education Level: Ph.D. or professional degree
• Number of Employees: 51-100 employees