Principal Scientist, Velocigene- Design & Molecular Biology
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About The Position
Regeneron seeks a highly motivated and creative molecular biologist to join our VelociGene team. This is an excellent opportunity for a Principal Scientist to work closely with key research and production groups in order to create best-in-class preclinical models and to innovate on key aspects of our pipeline, with a special focus on long-read sequencing platforms that will enable us to investigate the role of structural variation and genome integrity. As a Principal Scientist, a typical day might include the following: Work with VelociGene and Regeneron colleagues to develop, implement, and innovate on molecular biology techniques, focusing on long-read sequencing platforms. Optimize wet lab molecular biology techniques including high-quality nucleic acid extraction from various tissues and cells, library preparation, and process improvement. Perform robust data quality control and cross-validation. Assist collaborators and the team in designing, implementing, and validating novel algorithms to support various projects including but not limited to DNA structural variation and genome integrity studies. Develop additional expertise in various quantitative and qualitative methods to analyze nucleic acid composition and structure (e.g. microsatellites) as well as single-cell sequencing. Independently create and execute scientifically sound experimental plans using realistic and achievable project timelines and goals. Present results to management and at cross-group meetings. Contribute toward writing protocols and best practices in order to standardize established workflows and to collaborate toward database solutions. Use scientific literature to develop scientific arguments for project justifications, investigation conclusions, new technology, and process improvement ideas. Stay at the leading edge of models development and related technologies by attending relevant conferences and trainings.
