Principal Scientist Translational Science – Neurodegeneration or Renal Disease

GSK • Upper Providence Township, PA

116d

About The Position

As a Principal Scientist in the Translational Unit, working in Neurodegeneration or Renal Disease, you will play a critical role in bridging preclinical and early clinical proof of concept studies by designing and performing translational assays in human-derived cells, tissues, and biofluids. This is a lab-based position with mandatory on-site presence at either the Upper Providence, Pennsylvania (USA) or Stevenage (UK) laboratory sites. This role will provide YOU the opportunity to lead key activities to progress YOUR career.

Requirements

• PhD in a scientific discipline (e.g., Molecular Biology, Genetics, Immunology, or related field) with relevant laboratory experience.
• 4+ years’ experience in translational and biomarker development.
• Experience with handling of primary human cells and laboratory techniques such as immunoassays (ELISA, MSD, Quanterix), multi-color flow cytometry, and gene expression analysis.
• Experience in renal disease or neurodegeneration disease areas.

Nice To Haves

• Excellent problem-solving skills and ability to critically analyze scientific data.
• Strong written and verbal communication skills, with the ability to effectively present scientific findings to multidisciplinary internal and external stakeholders in a balanced, clear, and precise manner.
• Proven ability to balance priorities across multiple objectives, meeting timelines while maintaining attention to detail and high-performance standards.
• Able to independently define strategic approach to tackle specific project or department goals.
• Ability to work independently as well as collaboratively in a team-oriented environment.
• Resourcefulness to access cutting-edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities.

Responsibilities

• Design and execute laboratory experiments to advance scientific understanding and support drug discovery in neurodegeneration or renal disease.
• Support identification and validation of clinical biomarkers and development of clinically deployable biomarker assays.
• Apply expertise in multiple capabilities such as ELISA/MSD/Quanterix, Western/JESS, flow cytometry, gene/protein expression analysis, proteomics, and other omics platforms.
• Troubleshoot assays effectively and develop alternative approaches when necessary, working closely with preclinical statistics and other relevant teams to ensure robust study design.
• Maintain accurate and detailed laboratory records in alignment with data integrity expectations and ensure compliance with all relevant protocols and safety guidelines.

What This Job Offers

• Career Level: Senior
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees